Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.

Literature DB >> 22351749

Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.

Adriana Estrada-Bernal¹, Kamalakannan Palanichamy, Abhik Ray Chaudhury, James R Van Brocklyn.

Abstract

FTY720 is a sphingosine analogue that down regulates expression of sphingosine-1-phosphate receptors and causes apoptosis of multiple tumor cell types, including glioma cells. This study examined the effect of FTY720 on brain tumor stem cells (BTSCs) derived from human glioblastoma (GBM) tissue. FTY720 treatment of BTSCs led to rapid inactivation of ERK MAP kinase, leading to upregulation of the BH3-only protein Bim and apoptosis. In combination with temozolomide (TMZ), the current standard chemotherapeutic agent for GBM, FTY720 synergistically induced BTSC apoptosis. FTY720 also slowed growth of intracranial xenograft tumors in nude mice and augmented the therapeutic effect of TMZ, leading to enhanced survival. Furthermore, the combination of FTY720 and TMZ decreased the invasiveness of BTSCs in mouse brains. FTY720 is known to cross the blood-brain barrier and recently received Food and Drug Administration approval for treatment of relapsing multiple sclerosis. Thus, FTY720 is an excellent potential therapeutic agent for treatment of GBM.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2012 PMID： 22351749 PMCID： PMC3309856 DOI： 10.1093/neuonc/nos005

Source DB: PubMed Journal: Neuro Oncol ISSN： 1522-8517 Impact factor: 12.300

62 in total

1. Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation.

Authors: J D Wang; S Takahara; N Nonomura; N Ichimaru; K Toki; H Azuma; K Matsumiya; A Okuyama; S Suzuki
Journal: Prostate Date: 1999-06-15 Impact factor: 4.104

2. Isolation of cancer stem cells from adult glioblastoma multiforme.

Authors: Xiangpeng Yuan; James Curtin; Yizhi Xiong; Gentao Liu; Sebastian Waschsmann-Hogiu; Daniel L Farkas; Keith L Black; John S Yu
Journal: Oncogene Date: 2004-12-16 Impact factor: 9.867

3. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

Authors: M Esteller; S R Hamilton; P C Burger; S B Baylin; J G Herman
Journal: Cancer Res Date: 1999-02-15 Impact factor: 12.701

4. FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.

Authors: Hiroshi Yasui; Teru Hideshima; Noopur Raje; Aldo M Roccaro; Norihiko Shiraishi; Shaji Kumar; Makoto Hamasaki; Kenji Ishitsuka; Yu-Tzu Tai; Klaus Podar; Laurence Catley; Constantine S Mitsiades; Paul G Richardson; Rainer Albert; Volker Brinkmann; Dharminder Chauhan; Kenneth C Anderson
Journal: Cancer Res Date: 2005-08-15 Impact factor: 12.701

5. Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines.

Authors: James R Van Brocklyn; Catherine A Jackson; Dennis K Pearl; Mark S Kotur; Pamela J Snyder; Thomas W Prior
Journal: J Neuropathol Exp Neurol Date: 2005-08 Impact factor: 3.685

6. Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

Authors: Frederic Luciano; Arnaud Jacquel; Pascal Colosetti; Magali Herrant; Sebastien Cagnol; Gilles Pages; Patrick Auberger
Journal: Oncogene Date: 2003-10-02 Impact factor: 9.867

7. Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment.

Authors: Haruhito Azuma; Shigero Takahara; Shigeo Horie; Satoru Muto; Yoshinori Otsuki; Yoji Katsuoka
Journal: J Urol Date: 2003-06 Impact factor: 7.450

8. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma.

Authors: Rossella Galli; Elena Binda; Ugo Orfanelli; Barbara Cipelletti; Angela Gritti; Simona De Vitis; Roberta Fiocco; Chiara Foroni; Francesco Dimeco; Angelo Vescovi
Journal: Cancer Res Date: 2004-10-01 Impact factor: 12.701

9. Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity.

Authors: Haruhito Azuma; Shigeo Horie; Satoru Muto; Yoshinori Otsuki; Kenji Matsumoto; Junji Morimoto; Rieko Gotoh; Akihiko Okuyama; Seiichi Suzuki; Yoji Katsuoka; Shiro Takahara
Journal: Anticancer Res Date: 2003 Jul-Aug Impact factor: 2.480

10. Identification of human brain tumour initiating cells.

Authors: Sheila K Singh; Cynthia Hawkins; Ian D Clarke; Jeremy A Squire; Jane Bayani; Takuichiro Hide; R Mark Henkelman; Michael D Cusimano; Peter B Dirks
Journal: Nature Date: 2004-11-18 Impact factor: 49.962

35 in total

1. Alteration of DNA damage signaling pathway profile in radiation-treated glioblastoma stem-like cells.

Authors: Chao Sun; Zhongyong Wang; Wuchao Song; Baomin Chen; Jinshi Zhang; Xingliang Dai; Lin Wang; Jinding Wu; Qing Lan; Qiang Huang; Jun Dong
Journal: Oncol Lett Date: 2015-06-22 Impact factor: 2.967

Review 2. Targeting survival pathways in chronic myeloid leukaemia stem cells.

Authors: A Sinclair; A L Latif; T L Holyoake
Journal: Br J Pharmacol Date: 2013-08 Impact factor: 8.739

3. The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas.

Authors: Karl Quint; Norbert Stiel; Daniel Neureiter; Hans Ulrich Schlicker; Christopher Nimsky; Matthias Ocker; Herwig Strik; Malgorzata Anna Kolodziej
Journal: Tumour Biol Date: 2014-06-06

4. Fingolimod affects gene expression profile associated with LPS-induced memory impairment.

Authors: Rana Omidbakhsh; Banafshe Rajabli; Sanaz Nasoohi; Behzad Khallaghi; Zahurin Mohamed; Murali Naidu; Abolhassan Ahmadiani; Leila Dargahi
Journal: Exp Brain Res Date: 2014-08-07 Impact factor: 1.972

5. Glioblastoma following treatment with fingolimod for relapsing-remitting multiple sclerosis.

Authors: Justin Sharim; Randy Tashjian; Nima Golzy; Nader Pouratian
Journal: J Clin Neurosci Date: 2016-03-09 Impact factor: 1.961

6. FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway.

Authors: Mei-Hong Li; Timothy Hla; Fernando Ferrer
Journal: Pediatr Blood Cancer Date: 2013-05-23 Impact factor: 3.167