Literature DB >> 22351093

The spared nerve injury model of neuropathic pain.

Marie Pertin1, Romain-Daniel Gosselin, Isabelle Decosterd.   

Abstract

The spared nerve injury (SNI) model mimics human neuropathic pain related to peripheral nerve injury and is based upon an invasive but simple surgical procedure. Since its first description in 2000, it has displayed a remarkable development. It produces a robust, reliable and long-lasting neuropathic pain-like behaviour (allodynia and hyperalgesia) as well as the possibility of studying both injured and non-injured neuronal populations in the same spinal ganglion. Besides, variants of the SNI model have been developed in rats, mice and neonatal/young rodents, resulting in several possible angles of analysis. Therefore, the purpose of this chapter is to provide a detailed guidance regarding the SNI model and its variants, highlighting its surgical and behavioural testing specificities.

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Year:  2012        PMID： 22351093     DOI： 10.1007/978-1-61779-561-9_15

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  18 in total

1.  Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation.

Authors:  Rebecca McKelvey; Temugin Berta; Elizabeth Old; Ru-Rong Ji; Maria Fitzgerald
Journal:  J Neurosci       Date:  2015-01-14       Impact factor: 6.167

2.  The Red Nucleus Interleukin-6 Participates in the Maintenance of Neuropathic Pain Induced by Spared Nerve Injury.

Authors:  Cui-Ping Ding; Yu-Shun Xue; Jing Yu; Yi-Jie Guo; Xiao-Yan Zeng; Jun-Yang Wang
Journal:  Neurochem Res       Date:  2016-08-03       Impact factor: 3.996

3.  The Ups and Downs of Endocannabinoid Signaling in Chronic Pain-Induced Depression.

Authors:  Nicole Wilkinson
Journal:  J Neurosci       Date:  2022-03-16       Impact factor: 6.709

4.  Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity.

Authors:  Ming-Dong Zhang; Jie Su; Csaba Adori; Valentina Cinquina; Katarzyna Malenczyk; Fatima Girach; Changgeng Peng; Patrik Ernfors; Peter Löw; Lotta Borgius; Ole Kiehn; Masahiko Watanabe; Mathias Uhlén; Nicholas Mitsios; Jan Mulder; Tibor Harkany; Tomas Hökfelt
Journal:  J Clin Invest       Date:  2018-07-30       Impact factor: 14.808

5.  Cortex glial cells activation, associated with lowered mechanical thresholds and motor dysfunction, persists into adulthood after neonatal pain.

Authors:  Luciana Sayuri Sanada; Karina Laurenti Sato; Nathalia Leilane Berto Machado; Elisabete de Cássia do Carmo; Kathleen A Sluka; Valeria Paula Sassoli Fazan
Journal:  Int J Dev Neurosci       Date:  2014-03-22       Impact factor: 2.457

6.  Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration.

Authors:  Ruxandra Anton; Mihail Ghenghea; Violeta Ristoiu; Christophe Gattlen; Marc-Rene Suter; Petre Alexandru Cojocaru; Aurel Popa-Wagner; Bogdan Catalin; Alexandru-Florian Deftu
Journal:  Int J Mol Sci       Date:  2021-02-19       Impact factor: 5.923

7.  Sustained relief of neuropathic pain by AAV-targeted expression of CBD3 peptide in rat dorsal root ganglion.

Authors:  G Fischer; B Pan; D Vilceanu; Q H Hogan; H Yu
Journal:  Gene Ther       Date:  2013-10-24       Impact factor: 5.250

8.  Is there a reasonable excuse for not providing post-operative analgesia when using animal models of peripheral neuropathic pain for research purposes?

Authors:  Sara Hestehave; Gordon Munro; Rie Christensen; Tina Brønnum Pedersen; Lars Arvastson; Philip Hougaard; Klas S P Abelson
Journal:  PLoS One       Date:  2017-11-22       Impact factor: 3.240

9.  Antinociceptive properties of an isoform-selective inhibitor of Nav1.7 derived from saxitoxin in mouse models of pain.

Authors:  Jacob T Beckley; Hassan Pajouhesh; George Luu; Sheri Klas; Anton Delwig; Dennis Monteleone; Xiang Zhou; Denise Giuvelis; Ian D Meng; David C Yeomans; John C Hunter; John V Mulcahy
Journal:  Pain       Date:  2021-04-01       Impact factor: 7.926

10.  Reverse transcription quantitative real-time polymerase chain reaction reference genes in the spared nerve injury model of neuropathic pain: validation and literature search.

Authors:  Nicolas Piller; Isabelle Decosterd; Marc R Suter
Journal:  BMC Res Notes       Date:  2013-07-10
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