Literature DB >> 22351068

Synaptic pathology of Down syndrome.

Craig C Garner1, Daniel Z Wetmore.   

Abstract

Down syndrome is characterized by mild to moderate cognitive impairments that are caused by trisomy of chromosome 21. Several anatomical, behavioral, electrophysiological, and developmental abnormalities have been associated with Down syndrome. In this review, the current knowledge about the neurobiology of this disease and future perspectives of pharmacological treatments for this condition will be discussed.

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Year:  2012        PMID： 22351068     DOI： 10.1007/978-3-7091-0932-8_20

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  15 in total

1.  Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a.

Authors:  Aurore Thomazeau; Olivier Lassalle; Jillian Iafrati; Benoit Souchet; Fayçal Guedj; Nathalie Janel; Pascale Chavis; Jean Delabar; Olivier J Manzoni
Journal:  J Neurosci       Date:  2014-01-22       Impact factor: 6.167

2.  NEXMIF/KIDLIA Knock-out Mouse Demonstrates Autism-Like Behaviors, Memory Deficits, and Impairments in Synapse Formation and Function.

Authors:  James Gilbert; Margaret O'Connor; Sebastian Templet; Mahsa Moghaddam; Anaïs Di Via Ioschpe; Amanda Sinclair; Ling-Qiang Zhu; Weifeng Xu; Heng-Ye Man
Journal:  J Neurosci       Date:  2019-11-08       Impact factor: 6.167

3.  Dynamic balance of excitation and inhibition rapidly modulates spike probability and precision in feed-forward hippocampal circuits.

Authors:  Sarah Wahlstrom-Helgren; Vitaly A Klyachko
Journal:  J Neurophysiol       Date:  2016-09-07       Impact factor: 2.714

Review 4.  Human Models Are Needed for Studying Human Neurodevelopmental Disorders.

Authors:  Xinyu Zhao; Anita Bhattacharyya
Journal:  Am J Hum Genet       Date:  2018-12-06       Impact factor: 11.025

Review 5.  The penalty of stress - Epichaperomes negatively reshaping the brain in neurodegenerative disorders.

Authors:  Stephen D Ginsberg; Suhasini Joshi; Sahil Sharma; Gianny Guzman; Tai Wang; Ottavio Arancio; Gabriela Chiosis
Journal:  J Neurochem       Date:  2021-10-31       Impact factor: 5.372

6.  Loss of function of KIAA2022 causes mild to severe intellectual disability with an autism spectrum disorder and impairs neurite outgrowth.

Authors:  Lionel Van Maldergem; Qingming Hou; Vera M Kalscheuer; Marlène Rio; Martine Doco-Fenzy; Ana Medeira; Arjan P M de Brouwer; Christelle Cabrol; Stefan A Haas; Pierre Cacciagli; Sébastien Moutton; Emilie Landais; Jacques Motte; Laurence Colleaux; Céline Bonnet; Laurent Villard; Juliette Dupont; Heng-Ye Man
Journal:  Hum Mol Genet       Date:  2013-04-24       Impact factor: 6.150

Review 7.  Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disorders.

Authors:  Takatoshi Karasawa; Paul J Lombroso
Journal:  Neurosci Res       Date:  2014-09-10       Impact factor: 3.304

8.  Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase.

Authors:  Tyler D Baguley; Hai-Chao Xu; Manavi Chatterjee; Angus C Nairn; Paul J Lombroso; Jonathan A Ellman
Journal:  J Med Chem       Date:  2013-10-01       Impact factor: 7.446

9.  Human iPSC-derived Down syndrome astrocytes display genome-wide perturbations in gene expression, an altered adhesion profile, and increased cellular dynamics.

Authors:  Blandine Ponroy Bally; W Todd Farmer; Emma V Jones; Selin Jessa; J Benjamin Kacerovsky; Alexandre Mayran; Huashan Peng; Julie L Lefebvre; Jacques Drouin; Arnold Hayer; Carl Ernst; Keith K Murai
Journal:  Hum Mol Genet       Date:  2020-03-27       Impact factor: 6.150

10.  Proceedings of the 2013 annual meeting of the Fetal Alcohol Spectrum Disorders Study Group.

Authors:  Julie A Kable; James N Reynolds; C Fernando Valenzuela; Alexandre E Medina
Journal:  Alcohol       Date:  2014-08-08       Impact factor: 2.405
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