Literature DB >> 22349783

The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the σ-1 receptor.

K Sahlholm, P Århem, K Fuxe, D Marcellino.   

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Year:  2012        PMID: 22349783     DOI: 10.1038/mp.2012.3

Source DB:  PubMed          Journal:  Mol Psychiatry        ISSN: 1359-4184            Impact factor:   15.992


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  28 in total

1.  Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor.

Authors:  Chelsy R Eddings; Nicolas Arbez; Sergey Akimov; Michal Geva; Michael R Hayden; Christopher A Ross
Journal:  Neurobiol Dis       Date:  2019-05-17       Impact factor: 5.996

2.  The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease.

Authors:  Daniel Ryskamp; Jun Wu; Michal Geva; Rebecca Kusko; Iris Grossman; Michael Hayden; Ilya Bezprozvanny
Journal:  Neurobiol Dis       Date:  2016-11-03       Impact factor: 5.996

Review 3.  Therapeutic approaches to Huntington disease: from the bench to the clinic.

Authors:  Nicholas S Caron; E Ray Dorsey; Michael R Hayden
Journal:  Nat Rev Drug Discov       Date:  2018-09-21       Impact factor: 84.694

Review 4.  The Efficacy and Safety of Pridopidine on Treatment of Patients with Huntington's Disease: A Systematic Review and Meta-Analysis.

Authors:  Moamen Mostafa Asla; Asmaa Ahmed Nawar; Alaa Abdelsalam; Esraa Elsayed; Marwa Abdelazim Rizk; Mohamed Alaa Hussein; Walaa A Kamel
Journal:  Mov Disord Clin Pract       Date:  2021-10-29

5.  The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects.

Authors:  Nelleke Tolboom; Henk W Berendse; Josee E Leysen; Maqsood Yaqub; Bart N M van Berckel; Robert C Schuit; Mirthe M Ponsen; Esther Bakker; Nikie J Hoetjes; Albert D Windhorst; Maria L Carlsson; Adriaan A Lammertsma; Arvid Carlsson
Journal:  Neuropsychopharmacology       Date:  2014-08-05       Impact factor: 7.853

6.  The dopaminergic stabilizer pridopidine increases neuronal activity of pyramidal neurons in the prefrontal cortex.

Authors:  Benjamin Gronier; Susanna Waters; Henrik Ponten
Journal:  J Neural Transm (Vienna)       Date:  2013-03-07       Impact factor: 3.575

7.  Effects of the monoamine stabilizer (-)-OSU6162 on locomotor and sensorimotor responses predictive of antipsychotic activity.

Authors:  Vívian T da Silveira; Jivago Röpke; Ana L Matosinhos; Ana C Issy; Elaine A Del Bel; Antônio C de Oliveira; Fabrício A Moreira
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2018-04-24       Impact factor: 3.000

8.  Pridopidine for the Improvement of Motor Function in Patients With Huntington's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Authors:  Shujun Chen; Tianyu Liang; Tao Xue; Shouru Xue; Qun Xue
Journal:  Front Neurol       Date:  2021-05-13       Impact factor: 4.003

9.  The monoamine stabilizer OSU6162 has anxiolytic-like properties and reduces voluntary alcohol intake in a genetic rat model of depression.

Authors:  Aleksander A Mathé; Pia Steensland; Philippe A Melas; Malin Wirf; Helder André; Nitya Jayaram-Lindström
Journal:  Sci Rep       Date:  2021-06-04       Impact factor: 4.379

10.  Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor.

Authors:  Daniel Ryskamp; Lili Wu; Jun Wu; Dabin Kim; Gerhard Rammes; Michal Geva; Michael Hayden; Ilya Bezprozvanny
Journal:  Neurobiol Dis       Date:  2018-12-27       Impact factor: 5.996

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