INTRODUCTION: Severe acute asthma in children is associated with substantial morbidity and may require pediatric ICU (PICU) admission. The aim of the study was to determine risk factors for PICU admission. METHODS: The study used a retrospective multicenter case-control design. The cases included children admitted to the PICU because of severe acute asthma and a history of out-patient treatment by pediatricians or pediatric pulmonologists. Controls were children with asthma without a PICU admission for severe acute asthma. The children were matched for sex, age, hospital, and time elapsed since the diagnosis of asthma. Fourteen possible risk factors were analyzed. RESULTS: Sixty-six cases were matched to 164 controls. In univariate analysis, all but one of the analyzed variables were significantly associated with PICU-hospitalization. After multivariate conditional logistic regression analysis, 4 risk factors remained significant. These included active or passive smoking, allergies, earlier hospitalization for asthma, and non-sanitized home. CONCLUSIONS: Physicians and parents should be aware of these risk factors, and efforts should be made to counteract them. Copyright 2012 Daedalus Enterprises
INTRODUCTION: Severe acute asthma in children is associated with substantial morbidity and may require pediatric ICU (PICU) admission. The aim of the study was to determine risk factors for PICU admission. METHODS: The study used a retrospective multicenter case-control design. The cases included children admitted to the PICU because of severe acute asthma and a history of out-patient treatment by pediatricians or pediatric pulmonologists. Controls were children with asthma without a PICU admission for severe acute asthma. The children were matched for sex, age, hospital, and time elapsed since the diagnosis of asthma. Fourteen possible risk factors were analyzed. RESULTS: Sixty-six cases were matched to 164 controls. In univariate analysis, all but one of the analyzed variables were significantly associated with PICU-hospitalization. After multivariate conditional logistic regression analysis, 4 risk factors remained significant. These included active or passive smoking, allergies, earlier hospitalization for asthma, and non-sanitized home. CONCLUSIONS: Physicians and parents should be aware of these risk factors, and efforts should be made to counteract them. Copyright 2012 Daedalus Enterprises
Authors: Shelley A Boeschoten; Annemie L Boehmer; Peter J Merkus; Joost van Rosmalen; Johan C de Jongste; Pieter L A Fraaij; Richard Molenkamp; Sabien G Heisterkamp; Job B van Woensel; Berber Kapitein; Eric G Haarman; Roelie M Wösten-van Asperen; Martin C Kneyber; Joris Lemson; Stan Hartman; Dick A van Waardenburg; Heleen E Bunker-Wiersma; Carole N Brouwer; Bart E van Ewijk; Anneke M Landstra; Mariel Verwaal; Anja A Vaessen-Verberne; Sanne Hammer; Corinne M Buysse; Matthijs de Hoog Journal: ERJ Open Res Date: 2020-08-17
Authors: Shelley A Boeschoten; Corinne M P Buysse; Peter J F M Merkus; Jacob M C van Wijngaarden; Sabien G J Heisterkamp; Johan C de Jongste; Joost van Rosmalen; Suzan C M Cochius-den Otter; Annemie L M Boehmer; Matthijs de Hoog Journal: Pediatr Pulmonol Date: 2018-04-10