AIM: To introduce an approach for the detection of putative genetic host factors that predispose patients to develop head and neck squamous cell carcinomas (HNSCC). METHODS: HNSCC most often result from the accumulation of somatic gene alterations found in tumor cells. A cancer-predisposing genetic background must be expected in individuals who develop multiple cancers, starting at an unexpectedly young age or with little carcinogen exposure. Genome-wide loss of heterozygosity (LOH) profiling by single nucleotide polymorphism microarray mapping was performed in a patient with a remarkable history of multifocal HNSCC. RESULTS: Regions of genomic deletions in germline DNA were identified on several chromosomes with a remarkable size between 1.6 Mb and 8.1 Mb (mega base-pair). No LOH was detected at the genomic location of the tumor suppressor gene P53. CONCLUSION: Specific patterns of germline DNA deletions may be responsible for susceptibility to HNSCC and should be further analyzed.
AIM: To introduce an approach for the detection of putative genetic host factors that predispose patients to develop head and neck squamous cell carcinomas (HNSCC). METHODS: HNSCC most often result from the accumulation of somatic gene alterations found in tumor cells. A cancer-predisposing genetic background must be expected in individuals who develop multiple cancers, starting at an unexpectedly young age or with little carcinogen exposure. Genome-wide loss of heterozygosity (LOH) profiling by single nucleotide polymorphism microarray mapping was performed in a patient with a remarkable history of multifocal HNSCC. RESULTS: Regions of genomic deletions in germline DNA were identified on several chromosomes with a remarkable size between 1.6 Mb and 8.1 Mb (mega base-pair). No LOH was detected at the genomic location of the tumor suppressor gene P53. CONCLUSION: Specific patterns of germline DNA deletions may be responsible for susceptibility to HNSCC and should be further analyzed.
Entities:
Keywords:
Genome-wide analysis; Head and neck cancer; Loss of heterozygosity; Multifocal cancer; Single nucleotide polymorphism microarray; Squamous cell carcinoma
Authors: Jeremy A Squire; Jane Bayani; Catherine Luk; Lianne Unwin; Jason Tokunaga; Christina MacMillan; Jonathan Irish; Dale Brown; Patrick Gullane; Suzanne Kamel-Reid Journal: Head Neck Date: 2002-09 Impact factor: 3.147
Authors: M W Lingen; K W Chang; S J McMurray; D B Solt; M S Kies; B B Mittal; G K Haines; H J Pelzer Journal: Head Neck Date: 2000-07 Impact factor: 3.147
Authors: Betty C Tong; Karan Dhir; Patrick K Ha; William H Westra; Blanche P Alter; David Sidransky; Wayne M Koch; Joseph A Califano Journal: Head Neck Date: 2004-04 Impact factor: 3.147