Literature DB >> 22346455

Extrapulmonary abscess formation due to Pseudomonas cepacia in a cystic fibrosis patient.

J M Langley1, E L Ford-Jones, D C Armstrong, R Gold, S Read, H Levison.   

Abstract

A 19-year-old immunocompetent cystic fibrosis patient with recurrent neck abscesses due to a multiresistant Pseudomonas cepacia is described. After 13 drainage procedures over a two-year period, a trial of interferon-gamma therapy to enhance monocyte function was attempted. The patient had one minor recurrence but has otherwise been symptom free for almost two years. P cepacia is an unusual cause of extrapulmonary abscess formation. Such abscesses may not present with classical signs of inflammation, are likely to be multiresistant and to require surgical drainage. Immunotherapy may be justified in the immunocompetent host when infection is refractory to medical and surgical therapy.

Entities:  

Keywords:  Abscess; Cystic fibrosis; Interferon-gamma; Pseudomonas cepacia

Year:  1993        PMID: 22346455      PMCID: PMC3250793          DOI: 10.1155/1993/829573

Source DB:  PubMed          Journal:  Can J Infect Dis        ISSN: 1180-2332


  14 in total

1.  Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes.

Authors:  R D Nelson; P G Quie; R L Simmons
Journal:  J Immunol       Date:  1975-12       Impact factor: 5.422

2.  Hepatic abscess and cystic fibrosis.

Authors:  G J Canny
Journal:  Postgrad Med J       Date:  1989-07       Impact factor: 2.401

3.  Immune interferon enhances functional properties of human granulocytes: role of Fc receptors and effect of lymphotoxin, tumor necrosis factor, and granulocyte-macrophage colony-stimulating factor.

Authors:  B Perussia; M Kobayashi; M E Rossi; I Anegon; G Trinchieri
Journal:  J Immunol       Date:  1987-02-01       Impact factor: 5.422

Review 4.  Infection in patients with cystic fibrosis.

Authors:  T T Rubio
Journal:  Am J Med       Date:  1986-07-28       Impact factor: 4.965

5.  X-linked inheritance in females with chronic granulomatous disease.

Authors:  E L Mills; K S Rholl; P G Quie
Journal:  J Clin Invest       Date:  1980-08       Impact factor: 14.808

6.  Characterization of Pseudomonas cepacia isolates from patients with cystic fibrosis.

Authors:  A I McKevitt; D E Woods
Journal:  J Clin Microbiol       Date:  1984-02       Impact factor: 5.948

7.  Effect of Pseudomonas cepacia colonization on survival and pulmonary function of cystic fibrosis patients.

Authors:  L O Lewin; P J Byard; P B Davis
Journal:  J Clin Epidemiol       Date:  1990       Impact factor: 6.437

8.  Antibiotic resistance of Pseudomonas species.

Authors:  A Prince
Journal:  J Pediatr       Date:  1986-05       Impact factor: 4.406

9.  Purification and characterization of an extracellular protease from Pseudomonas cepacia.

Authors:  A I McKevitt; S Bajaksouzian; J D Klinger; D E Woods
Journal:  Infect Immun       Date:  1989-03       Impact factor: 3.441

Review 10.  Interferon-gamma in the management of chronic granulomatous disease.

Authors:  J I Gallin
Journal:  Rev Infect Dis       Date:  1991 Sep-Oct
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