Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Chloride in airway smooth muscle: the ignored anion no longer?

Literature DB >> 22345576

Chloride in airway smooth muscle: the ignored anion no longer?

George Gallos¹, Peter Yim, Charles W Emala.

Abstract

This Perspectives accompanies an Editorial Focus that summarizes new developments concerning the role of chloride in airway smooth muscle physiology. We provide several observations and mechanistic insights to reconcile recent experimental evidence with existing paradigms concerning chloride channel-mediated effects on airway smooth muscle tone. In addition, we highlight the potentially complex and dynamic nature that chloride currents and membrane potential have on calcium handling and airway smooth muscle contractility.

Entities: Chemical

Mesh：

Substances：

Year: 2012 PMID： 22345576 PMCID： PMC3774086 DOI： 10.1152/ajplung.00053.2012

Source DB: PubMed Journal: Am J Physiol Lung Cell Mol Physiol ISSN： 1040-0605 Impact factor: 5.464

29 in total

1. Different inhibitory effects of volatile anesthetics on T- and L-type voltage-dependent Ca2+ channels in porcine tracheal and bronchial smooth muscles.

Authors: M Yamakage; X Chen; N Tsujiguchi; Y Kamada; A Namiki
Journal: Anesthesiology Date: 2001-04 Impact factor: 7.892

Review 2. Ionic mechanisms and Ca(2+) regulation in airway smooth muscle contraction: do the data contradict dogma?

Authors: Luke J Janssen
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2002-06 Impact factor: 5.464

3. Airway smooth muscle electrophysiology in a state of flux?

Authors: Luke J Janssen
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2012-02-17 Impact factor: 5.464

4. Targeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxation.

Authors: George Gallos; Peter Yim; Sucie Chang; Yi Zhang; Dingbang Xu; James M Cook; William T Gerthoffer; Charles W Emala
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2011-09-23 Impact factor: 5.464

Chloride in airway smooth muscle: the ignored anion no longer?

1. Different inhibitory effects of volatile anesthetics on T- and L-type voltage-dependent Ca2+ channels in porcine tracheal and bronchial smooth muscles.

Review 2. Ionic mechanisms and Ca(2+) regulation in airway smooth muscle contraction: do the data contradict dogma?

3. Airway smooth muscle electrophysiology in a state of flux?

4. Targeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxation.

5. Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury.

6. The M2 muscarinic G-protein-coupled receptor is voltage-sensitive.

7. KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase.

Review 8. Formation of STIM and Orai complexes: puncta and distal caps.

Review 9. Synchronization of Ca2+ oscillations: a coupled oscillator-based mechanism in smooth muscle.

Review 10. Extrasynaptic GABAA receptors: form, pharmacology, and function.

1. CF airway smooth muscle transcriptome reveals a role for PYK2.

Review 2. Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones.

3. Can we find better bronchodilators to relieve asthma symptoms?