Literature DB >> 22345446

Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance.

Christopher W Seibert1, Saad Rahmat, Florian Krammer, Peter Palese, Nicole M Bouvier.   

Abstract

The limited availability of approved influenza virus antivirals highlights the importance of studying the fitness and transmissibility of drug-resistant viruses. S247N is a novel, naturally occurring N1 neuraminidase mutation that reduces oseltamivir sensitivity and greatly potentiates oseltamivir resistance in the context of the H275Y mutation. Here we show that highly oseltamivir-resistant viruses containing both the S247N and H275Y mutations transmit efficiently in the guinea pig transmission model.

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Year:  2012        PMID： 22345446      PMCID： PMC3347392          DOI： 10.1128/JVI.00151-12

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  32 in total

1.  The emergence of oseltamivir-resistant pandemic influenza A (H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009.

Authors:  H Harvala; R Gunson; P Simmonds; A Hardie; S Bennett; F Scott; H Roddie; J McKnight; T Walsh; D Rowney; A Clark; J Bremner; C Aitken; K Templeton
Journal:  Euro Surveill       Date:  2010-04-08

2.  The global spread of drug-resistant influenza.

Authors:  Dennis L Chao; Jesse D Bloom; Beth F Kochin; Rustom Antia; Ira M Longini
Journal:  J R Soc Interface       Date:  2011-08-24       Impact factor: 4.118

3.  Permissive secondary mutations enable the evolution of influenza oseltamivir resistance.

Authors:  Jesse D Bloom; Lizhi Ian Gong; David Baltimore
Journal:  Science       Date:  2010-06-04       Impact factor: 47.728

4.  Transmission of a 2009 pandemic influenza virus shows a sensitivity to temperature and humidity similar to that of an H3N2 seasonal strain.

Authors:  John Steel; Peter Palese; Anice C Lowen
Journal:  J Virol       Date:  2010-11-17       Impact factor: 5.103

5.  Evidence of person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus in a hematology unit.

Authors:  Catherine Moore; Monica Galiano; Angie Lackenby; Tamer Abdelrahman; Rosemary Barnes; Meirion R Evans; Christopher Fegan; Susannah Froude; Mark Hastings; Steven Knapper; Emma Litt; Nicola Price; Roland Salmon; Mark Temple; Eleri Davies
Journal:  J Infect Dis       Date:  2011-01-01       Impact factor: 5.226

6.  Oseltamivir-resistant pandemic H1N1/2009 influenza virus possesses lower transmissibility and fitness in ferrets.

Authors:  Susu Duan; David A Boltz; Patrick Seiler; Jiang Li; Karoline Bragstad; Lars P Nielsen; Richard J Webby; Robert G Webster; Elena A Govorkova
Journal:  PLoS Pathog       Date:  2010-07-29       Impact factor: 6.823

7.  Effect of the neuraminidase mutation H274Y conferring resistance to oseltamivir on the replicative capacity and virulence of old and recent human influenza A(H1N1) viruses.

Authors:  Mariana Baz; Yacine Abed; Philippe Simon; Marie-Eve Hamelin; Guy Boivin
Journal:  J Infect Dis       Date:  2010-03       Impact factor: 5.226

8.  Oseltamivir-resistant pandemic A/H1N1 virus is as virulent as its wild-type counterpart in mice and ferrets.

Authors:  Marie-Eve Hamelin; Mariana Baz; Yacine Abed; Christian Couture; Philippe Joubert; Edith Beaulieu; Nathalie Bellerose; Martin Plante; Corey Mallett; Gregg Schumer; Gary P Kobinger; Guy Boivin
Journal:  PLoS Pathog       Date:  2010-07-22       Impact factor: 6.823

9.  Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses.

Authors:  Maki Kiso; Kyoko Shinya; Masayuki Shimojima; Ryo Takano; Kei Takahashi; Hiroaki Katsura; Satoshi Kakugawa; Mai Thi Quynh Le; Makoto Yamashita; Yousuke Furuta; Makoto Ozawa; Yoshihiro Kawaoka
Journal:  PLoS Pathog       Date:  2010-08-26       Impact factor: 6.823

10.  Multidrug resistant 2009 A/H1N1 influenza clinical isolate with a neuraminidase I223R mutation retains its virulence and transmissibility in ferrets.

Authors:  Erhard van der Vries; Edwin J Veldhuis Kroeze; Koert J Stittelaar; Martin Linster; Anne Van der Linden; Eefje J A Schrauwen; Lonneke M Leijten; Geert van Amerongen; Martin Schutten; Thijs Kuiken; Albert D M E Osterhaus; Ron A M Fouchier; Charles A B Boucher; Sander Herfst
Journal:  PLoS Pathog       Date:  2011-09-29       Impact factor: 6.823
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  15 in total

1.  Enhanced mammalian transmissibility of seasonal influenza A/H1N1 viruses encoding an oseltamivir-resistant neuraminidase.

Authors:  Nicole M Bouvier; Saad Rahmat; Natalie Pica
Journal:  J Virol       Date:  2012-04-24       Impact factor: 5.103

2.  Ancestral and Compensatory Mutations that Promote Antiviral Resistance in Influenza N1 Neuraminidase Revealed by a Phylonumerics Approach.

Authors:  Elma H Akand; Kevin M Downard
Journal:  J Mol Evol       Date:  2018-10-09       Impact factor: 2.395

3.  The H275Y neuraminidase mutation of the pandemic A/H1N1 influenza virus lengthens the eclipse phase and reduces viral output of infected cells, potentially compromising fitness in ferrets.

Authors:  Lady Tatiana Pinilla; Benjamin P Holder; Yacine Abed; Guy Boivin; Catherine A A Beauchemin
Journal:  J Virol       Date:  2012-07-25       Impact factor: 5.103

Review 4.  Consequences of resistance: in vitro fitness, in vivo infectivity, and transmissibility of oseltamivir-resistant influenza A viruses.

Authors:  Elena A Govorkova
Journal:  Influenza Other Respir Viruses       Date:  2013-01       Impact factor: 4.380

5.  Resistance to Mutant Group 2 Influenza Virus Neuraminidases of an Oseltamivir-Zanamivir Hybrid Inhibitor.

Authors:  Yan Wu; Feng Gao; Jianxun Qi; Yuhai Bi; Lifeng Fu; Sankar Mohan; Yuhang Chen; Xuebing Li; B Mario Pinto; Christopher J Vavricka; Po Tien; George F Gao
Journal:  J Virol       Date:  2016-11-14       Impact factor: 5.103

6.  Recombinant IgA is sufficient to prevent influenza virus transmission in guinea pigs.

Authors:  Christopher W Seibert; Saad Rahmat; Jens C Krause; Dirk Eggink; Randy A Albrecht; Peter H Goff; Florian Krammer; J Andrew Duty; Nicole M Bouvier; Adolfo García-Sastre; Peter Palese
Journal:  J Virol       Date:  2013-05-22       Impact factor: 5.103

7.  Andrographolide as an anti-H1N1 drug and the mechanism related to retinoic acid-inducible gene-I-like receptors signaling pathway.

Authors:  Bin Yu; Cong-qi Dai; Zhen-you Jiang; En-qing Li; Chen Chen; Xian-lin Wu; Jia Chen; Qian Liu; Chang-lin Zhao; Jin-xiong He; Da-hong Ju; Xiao-yin Chen
Journal:  Chin J Integr Med       Date:  2014-06-28       Impact factor: 1.978

8.  Broadly Reactive Human Monoclonal Antibodies Elicited following Pandemic H1N1 Influenza Virus Exposure Protect Mice against Highly Pathogenic H5N1 Challenge.

Authors:  Raffael Nachbagauer; David Shore; Hua Yang; Scott K Johnson; Jon D Gabbard; S Mark Tompkins; Jens Wrammert; Patrick C Wilson; James Stevens; Rafi Ahmed; Florian Krammer; Ali H Ellebedy
Journal:  J Virol       Date:  2018-07-31       Impact factor: 5.103

9.  H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis.

Authors:  Erhard van der Vries; Patrick J Collins; Sebastien G Vachieri; Xiaoli Xiong; Junfeng Liu; Philip A Walker; Lesley F Haire; Alan J Hay; Martin Schutten; Albert D M E Osterhaus; Steve R Martin; Charles A B Boucher; John J Skehel; Steve J Gamblin
Journal:  PLoS Pathog       Date:  2012-09-20       Impact factor: 6.823

10.  Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibility.

Authors:  Rong Hai; Mirco Schmolke; Victor H Leyva-Grado; Rajagowthamee R Thangavel; Irina Margine; Eric L Jaffe; Florian Krammer; Alicia Solórzano; Adolfo García-Sastre; Peter Palese; Nicole M Bouvier
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919
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