INTRODUCTION: Viral hepatitis in children is a major public health problem worldwide. AIM: To evaluate the prevalence of serological markers for hepatitis A, B and C infections in Mexican children diagnosed with hepatitis during a five-year period. MATERIAL AND METHODS: A total of 31,818 children admitted to a tertiary level hospital in Mexico from 2005 to 2009 were evaluated for hepatitis. RESULTS: Hepatitis was found in 215 (0.7%) of the children. Serum samples from hepatitis-positive children were screened for anti-HAV IgM, HBsAg, total anti-HBc and anti-HCV. HAV was the leading cause of viral hepatitis (81%), followed by HBV and HCV (3.1 and 2%, respectively), whereas no serological marker was observed in 13.9% of the analyzed samples. Furthermore, when children were categorized by age, a significant increase in anti-HAV detection was observed in school-aged children (7-11 years old) (p < 0.001) and a reduction in adolescents (12-15 years old). CONCLUSION: In conclusion, hepatitis A is the most prevalent viral hepatitis infection detected in children, followed by HBV and HCV. In addition, the high percentage of hepatitis infections without a known etiological agent and the serological test limitations require the detection of occult HBV, HCV and hepatitis E infections. The age-dependent vulnerability of groups with HAV infections emphasizes the importance of HAV vaccination in young children in Mexico.
INTRODUCTION:Viral hepatitis in children is a major public health problem worldwide. AIM: To evaluate the prevalence of serological markers for hepatitis A, B and C infections in Mexican children diagnosed with hepatitis during a five-year period. MATERIAL AND METHODS: A total of 31,818 children admitted to a tertiary level hospital in Mexico from 2005 to 2009 were evaluated for hepatitis. RESULTS:Hepatitis was found in 215 (0.7%) of the children. Serum samples from hepatitis-positive children were screened for anti-HAV IgM, HBsAg, total anti-HBc and anti-HCV. HAV was the leading cause of viral hepatitis (81%), followed by HBV and HCV (3.1 and 2%, respectively), whereas no serological marker was observed in 13.9% of the analyzed samples. Furthermore, when children were categorized by age, a significant increase in anti-HAV detection was observed in school-aged children (7-11 years old) (p < 0.001) and a reduction in adolescents (12-15 years old). CONCLUSION: In conclusion, hepatitis A is the most prevalent viral hepatitis infection detected in children, followed by HBV and HCV. In addition, the high percentage of hepatitis infections without a known etiological agent and the serological test limitations require the detection of occult HBV, HCV and hepatitis E infections. The age-dependent vulnerability of groups with HAV infections emphasizes the importance of HAV vaccination in young children in Mexico.
Authors: Nora A Fierro; Karina González-Aldaco; Rafael Torres-Valadez; Maria E Trujillo-Trujillo; Sonia Roman; Jorge L Trujillo-Ochoa; Arturo Panduro Journal: Mem Inst Oswaldo Cruz Date: 2015-04-01 Impact factor: 2.743
Authors: Livia Melo Villar; Luciane Almeida Amado; Adilson José de Almeida; Vanessa Salete de Paula; Lia Laura Lewis-Ximenez; Elisabeth Lampe Journal: Biomed Res Int Date: 2014-07-01 Impact factor: 3.411
Authors: Maria Del Mar Bibiloni; Rogelio Salas; Georgina M Nuñez; Jesús Z Villarreal; Antoni Sureda; Josep A Tur Journal: PLoS One Date: 2016-05-20 Impact factor: 3.240