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Literature DB >> 22344034

Good neighbours in the tumour stroma reduce oxidative stress.

Abstract

Tumour cells undergo oncogene-regulated metabolic reprogramming that maximizes survival and growth. However, little is known about metabolic interactions between tumour cells and their non-malignant neighbours in the stroma. Bone-marrow-derived stromal cells are now shown to provide cysteine, an essential nutrient that enables leukaemia cells to resist oxidative stress.

Entities: Chemical Disease

Mesh：

Substances：
Cystine
Glutathione

Year: 2012 PMID： 22344034 DOI： 10.1038/ncb2449

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

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Review 3. Tumor-stroma interactions.

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3. Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle.

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4. Mathematical Modeling of the Function of Warburg Effect in Tumor Microenvironment.

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