OBJECTIVES: We investigated the potential association between serum cholesterol levels and coronary microvascular function, using the index of microvascular resistance (IMR), in patients with coronary artery disease. METHODS: At the time of coronary angiography, IMR was measured in one or more epicardial vessel with an intermediate stenosis (>30%). Total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein cholesterol and triglyceride concentrations were measured before cardiac catheterization. RESULTS: A total of 110 coronary arteries were investigated in 95 patients. The mean IMR was 26 ± 12 with evidence of microvascular dysfunction in 32 arteries (29%). A significant correlation was seen between IMR, total cholesterol (r=0.28, P=0.003) and LDL cholesterol (r=0.30, P=0.001). At multivariate analysis, LDL cholesterol was the only independent predictor of IMR, even after adjustment for the extent of epicardial coronary atherosclerosis and fractional flow reserve values. CONCLUSION: Our data obtained with invasive measurement of microvascular resistance suggest a significant correlation between cholesterol levels and coronary microvascular dysfunction.
OBJECTIVES: We investigated the potential association between serum cholesterol levels and coronary microvascular function, using the index of microvascular resistance (IMR), in patients with coronary artery disease. METHODS: At the time of coronary angiography, IMR was measured in one or more epicardial vessel with an intermediate stenosis (>30%). Total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein cholesterol and triglyceride concentrations were measured before cardiac catheterization. RESULTS: A total of 110 coronary arteries were investigated in 95 patients. The mean IMR was 26 ± 12 with evidence of microvascular dysfunction in 32 arteries (29%). A significant correlation was seen between IMR, total cholesterol (r=0.28, P=0.003) and LDL cholesterol (r=0.30, P=0.001). At multivariate analysis, LDL cholesterol was the only independent predictor of IMR, even after adjustment for the extent of epicardial coronary atherosclerosis and fractional flow reserve values. CONCLUSION: Our data obtained with invasive measurement of microvascular resistance suggest a significant correlation between cholesterol levels and coronary microvascular dysfunction.
Authors: Emanuele Barbato; Giovanna Sarno; Catalina Trana Berza; Giuseppe Di Gioia; Jozef Bartunek; Marc Vanderheyden; Luigi Di Serafino; William Wijns; Bruno Trimarco; Bernard De Bruyne Journal: J Cardiovasc Transl Res Date: 2014-11-01 Impact factor: 4.132
Authors: Henry Anselmo Mayala; Wang Yan; Hu Jing; Liu Shuang-Ye; Yi Gui-Wen; Qin Chun-Xia; Wang Ya; Lan Xiao-Li; Wang Zhao-Hui Journal: J Int Med Res Date: 2019-08-09 Impact factor: 1.671
Authors: Laurens Holmes; Alex LaHurd; Emily Wasson; Lavisha McClarin; Kirk Dabney Journal: Int J Environ Res Public Health Date: 2015-12-23 Impact factor: 3.390