Literature DB >> 22342631

Novel hepatitis C virus replicon inhibitors: synthesis and structure-activity relationships of fused pyrimidine derivatives.

A Chris Krueger1, Darold L Madigan, David W Beno, David A Betebenner, Robert Carrick, Brian E Green, Wenping He, Dachun Liu, Clarence J Maring, Keith F McDaniel, Hongmei Mo, Akhteruzzaman Molla, Christopher E Motter, Tami J Pilot-Matias, Michael D Tufano, Dale J Kempf.   

Abstract

The synthesis of several pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine analogs is described with one such analog possessing subnanomolar potency in both genotype 1a and 1b cell culture HCV replicon assays. Copyright Â
© 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22342631     DOI： 10.1016/j.bmcl.2012.01.096

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  t-Butyl pyridine and phenyl C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.

Authors:  Sunho Lee; Dong Wook Kang; HyungChul Ryu; Changhoon Kim; Jihyae Ann; Hobin Lee; Eunhye Kim; Sunhye Hong; Sun Choi; Peter M Blumberg; Robert Frank-Foltyn; Gregor Bahrenberg; Hannelore Stockhausen; Thomas Christoph; Jeewoo Lee
Journal:  Bioorg Med Chem       Date:  2017-03-06       Impact factor: 3.641

2.  Synthesis, X-ray and Fluorescence Characteristics of Pyrimido[5,4-e]thiazolo[3,2-a]pyrimidine as a Novel Heterocyclic System.

Authors:  Zahra Ebrahimpour; Mehdi Bakavoli; Ali Shiri; Seyed Mohammad Seyedi; Tayebe Asghari; Joel T Mague
Journal:  J Fluoresc       Date:  2017-03-10       Impact factor: 2.217

3.  Preparation of tetrasubstituted pyrimido[4,5-d]pyrimidine diones.

Authors:  Hui Wang; Chao Wang; Thomas D Bannister
Journal:  Tetrahedron Lett       Date:  2015-04-08       Impact factor: 2.415

4.  In vitro and in vivo antiviral activity and resistance profile of ombitasvir, an inhibitor of hepatitis C virus NS5A.

Authors:  Preethi Krishnan; Jill Beyer; Neeta Mistry; Gennadiy Koev; Thomas Reisch; David DeGoey; Warren Kati; Andrew Campbell; Laura Williams; Wangang Xie; Carolyn Setze; Akhteruzzaman Molla; Christine Collins; Tami Pilot-Matias
Journal:  Antimicrob Agents Chemother       Date:  2014-12-01       Impact factor: 5.191

5.  Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters.

Authors:  Huiwen Ren; Yanhua Wang; Yongning Xing; Jianhua Ran; Ming Liu; Tianluo Lei; Hong Zhou; Runtao Li; Jeff M Sands; Baoxue Yang
Journal:  Am J Physiol Renal Physiol       Date:  2014-10-08

6.  Towards a systematic assessment of assay interference: Identification of extensively tested compounds with high assay promiscuity.

Authors:  Erik Gilberg; Dagmar Stumpfe; Jürgen Bajorath
Journal:  F1000Res       Date:  2017-08-17

Review 7.  Bicyclic 6 + 6 systems: the chemistry of pyrimido[4,5-d]pyrimidines and pyrimido[5,4-d]pyrimidines.

Authors:  M Monier; Doaa Abdel-Latif; Ahmed El-Mekabaty; Khaled M Elattar
Journal:  RSC Adv       Date:  2019-09-30       Impact factor: 4.036

Review 8.  Advances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine scaffolds.

Authors:  Khaled M Elattar; Başak Doğru Mert; M Monier; Ahmed El-Mekabaty
Journal:  RSC Adv       Date:  2020-04-20       Impact factor: 4.036
  8 in total

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