BACKGROUND AND PURPOSE: Radiation induced lung fibrosis (RILF) is a major complication after lung irradiation and is very important for long term quality of life and could result in fatal respiratory insufficiency. However, there has been little information on dosimetric parameters for radiotherapy planning in the aspect of RILF. The features of RILF related with dosimetric parameters were evaluated. METHODS AND MATERIALS: Forty-eight patients with non-small cell lung carcinoma who underwent post-operative radiation therapy (PORT) without adjuvant chemotherapy were analyzed. The degree of lung fibrosis was estimated by fibrosis volume and the dosimetric parameters were calculated from the plan of 3-dimensional conformal radiotherapy. RESULTS: The fibrosis volume and V-dose as dosimetric parameters showed significant correlation and the correlation coefficient ranged from 0.602 to 0.683 (P<0.01). The degree of the correlation line was steeper as the dose increase and threshold dose was not found. Mean lung dose (MLD) showed strong correlation with fibrosis volume (correlation coefficient = 0.726, P<0.01). CONCLUSIONS: The fibrosis volume is continuously increased with V-dose as the reference dose increases. MLD is useful as a single parameter for comparing rival plans in the aspect of RILF.
BACKGROUND AND PURPOSE: Radiation induced lung fibrosis (RILF) is a major complication after lung irradiation and is very important for long term quality of life and could result in fatal respiratory insufficiency. However, there has been little information on dosimetric parameters for radiotherapy planning in the aspect of RILF. The features of RILF related with dosimetric parameters were evaluated. METHODS AND MATERIALS: Forty-eight patients with non-small cell lung carcinoma who underwent post-operative radiation therapy (PORT) without adjuvant chemotherapy were analyzed. The degree of lung fibrosis was estimated by fibrosis volume and the dosimetric parameters were calculated from the plan of 3-dimensional conformal radiotherapy. RESULTS: The fibrosis volume and V-dose as dosimetric parameters showed significant correlation and the correlation coefficient ranged from 0.602 to 0.683 (P<0.01). The degree of the correlation line was steeper as the dose increase and threshold dose was not found. Mean lung dose (MLD) showed strong correlation with fibrosis volume (correlation coefficient = 0.726, P<0.01). CONCLUSIONS: The fibrosis volume is continuously increased with V-dose as the reference dose increases. MLD is useful as a single parameter for comparing rival plans in the aspect of RILF.
Authors: Jennifer L Judge; Shannon H Lacy; Wei-Yao Ku; Kristina M Owens; Eric Hernady; Thomas H Thatcher; Jacqueline P Williams; Richard P Phipps; Patricia J Sime; R Matthew Kottmann Journal: Radiat Res Date: 2017-05-02 Impact factor: 2.841
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Authors: Matthew R McCurdy; Richard Castillo; Josue Martinez; Mohammad Najeeb Al Hallack; Jessica Lichter; Nicolas Zouain; Thomas Guerrero Journal: Radiother Oncol Date: 2012-05-10 Impact factor: 6.280
Authors: Philipp Hoegen; Clemens Lang; Sati Akbaba; Peter Häring; Mona Splinter; Annette Miltner; Marion Bachmann; Christiane Stahl-Arnsberger; Thomas Brechter; Rami A El Shafie; Fabian Weykamp; Laila König; Jürgen Debus; Juliane Hörner-Rieber Journal: Front Oncol Date: 2020-12-09 Impact factor: 6.244