| Literature DB >> 22342146 |
Siddheshwar K Chauthe1, Sandip B Bharate, Giridharan Periyasamy, Amit Khanna, Kamlesh K Bhutani, Prabhu D Mishra, Inder P Singh.
Abstract
A series of dimeric phloroglucinol compounds were synthesized in a single step using commercially available phloroglucinol and methanesulfonic acid. Based on the reported anticancer activity of plant derived dimeric phloroglucinols, these synthesized compounds were evaluated for their in vitro anti-proliferative activities against various cancer cell lines. Several compounds demonstrated in vitro cytotoxic effects across a wide array of tumor cell types. The compound 29 with pyridin-3-yl group on linker methylene and two diisovaleryl phloroglucinol moieties was found to be the most active in all the five cancer cell lines having a low IC(50) of 5.5 μM in colon cancer cell lines (HCT116). Copyright ÂEntities:
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Year: 2012 PMID： 22342146 DOI： 10.1016/j.bmcl.2012.01.089
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823