Literature DB >> 22341437

Telomeres and cancer: from crisis to stability to crisis to stability.

Peter J Campbell1.   

Abstract

Telomere attrition unleashes genomic instability, promoting cancer development. Once established, however, the malignant clone often re-establishes genomic stability through overexpression of telomerase. In two papers, one in this issue of Cell and one in the subsequent issue, DePinho and colleagues explore the consequences of telomerase re-expression and its validity as a therapeutic target in mouse models of cancer. Copyright Â
© 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 22341437      PMCID： PMC3322332          DOI： 10.1016/j.cell.2012.01.043

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  10 in total

1.  Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution.

Authors:  Graham R Bignell; Thomas Santarius; Jessica C M Pole; Adam P Butler; Janet Perry; Erin Pleasance; Chris Greenman; Andrew Menzies; Sheila Taylor; Sarah Edkins; Peter Campbell; Michael Quail; Bob Plumb; Lucy Matthews; Kirsten McLay; Paul A W Edwards; Jane Rogers; Richard Wooster; P Andrew Futreal; Michael R Stratton
Journal:  Genome Res       Date:  2007-08-03       Impact factor: 9.043

2.  Essential role of mouse telomerase in highly proliferative organs.

Authors:  H W Lee; M A Blasco; G J Gottlieb; J W Horner; C W Greider; R A DePinho
Journal:  Nature       Date:  1998-04-09       Impact factor: 49.962

3.  Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases.

Authors:  Zhihu Ding; Chang-Jiun Wu; Mariela Jaskelioff; Elena Ivanova; Maria Kost-Alimova; Alexei Protopopov; Gerald C Chu; Guocan Wang; Xin Lu; Emma S Labrot; Jian Hu; Wei Wang; Yonghong Xiao; Hailei Zhang; Jianhua Zhang; Jingfang Zhang; Boyi Gan; Samuel R Perry; Shan Jiang; Liren Li; James W Horner; Y Alan Wang; Lynda Chin; Ronald A DePinho
Journal:  Cell       Date:  2012-02-16       Impact factor: 41.582

4.  Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer.

Authors:  Jian Hu; Soyoon Sarah Hwang; Marc Liesa; Boyi Gan; Ergun Sahin; Mariela Jaskelioff; Zhihu Ding; Haoqiang Ying; Adam T Boutin; Hailei Zhang; Shawn Johnson; Elena Ivanova; Maria Kost-Alimova; Alexei Protopopov; Yaoqi Alan Wang; Orian S Shirihai; Lynda Chin; Ronald A DePinho
Journal:  Cell       Date:  2012-02-17       Impact factor: 41.582

5.  The patterns and dynamics of genomic instability in metastatic pancreatic cancer.

Authors:  Peter J Campbell; Shinichi Yachida; Laura J Mudie; Philip J Stephens; Erin D Pleasance; Lucy A Stebbings; Laura A Morsberger; Calli Latimer; Stuart McLaren; Meng-Lay Lin; David J McBride; Ignacio Varela; Serena A Nik-Zainal; Catherine Leroy; Mingming Jia; Andrew Menzies; Adam P Butler; Jon W Teague; Constance A Griffin; John Burton; Harold Swerdlow; Michael A Quail; Michael R Stratton; Christine Iacobuzio-Donahue; P Andrew Futreal
Journal:  Nature       Date:  2010-10-28       Impact factor: 49.962

6.  Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors.

Authors:  D Gisselsson; T Jonson; A Petersén; B Strömbeck; P Dal Cin; M Höglund; F Mitelman; F Mertens; N Mandahl
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-02       Impact factor: 11.205

7.  Telomere dysfunction provokes regional amplification and deletion in cancer genomes.

Authors:  Rónán C O'Hagan; Sandy Chang; Richard S Maser; Ramya Mohan; Steven E Artandi; Lynda Chin; Ronald A DePinho
Journal:  Cancer Cell       Date:  2002-08       Impact factor: 31.743

8.  Telomere shortening and telomerase expression during multistage carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas.

Authors:  Yasushi Hashimoto; Yoshiaki Murakami; Kenichiro Uemura; Yasuo Hayashidani; Takeshi Sudo; Hiroki Ohge; Emi Fukuda; Fumio Shimamoto; Taijiro Sueda; Eiso Hiyama
Journal:  J Gastrointest Surg       Date:  2008-01       Impact factor: 3.452

9.  The landscape of somatic copy-number alteration across human cancers.

Authors:  Rameen Beroukhim; Craig H Mermel; Dale Porter; Guo Wei; Soumya Raychaudhuri; Jerry Donovan; Jordi Barretina; Jesse S Boehm; Jennifer Dobson; Mitsuyoshi Urashima; Kevin T Mc Henry; Reid M Pinchback; Azra H Ligon; Yoon-Jae Cho; Leila Haery; Heidi Greulich; Michael Reich; Wendy Winckler; Michael S Lawrence; Barbara A Weir; Kumiko E Tanaka; Derek Y Chiang; Adam J Bass; Alice Loo; Carter Hoffman; John Prensner; Ted Liefeld; Qing Gao; Derek Yecies; Sabina Signoretti; Elizabeth Maher; Frederic J Kaye; Hidefumi Sasaki; Joel E Tepper; Jonathan A Fletcher; Josep Tabernero; José Baselga; Ming-Sound Tsao; Francesca Demichelis; Mark A Rubin; Pasi A Janne; Mark J Daly; Carmelo Nucera; Ross L Levine; Benjamin L Ebert; Stacey Gabriel; Anil K Rustgi; Cristina R Antonescu; Marc Ladanyi; Anthony Letai; Levi A Garraway; Massimo Loda; David G Beer; Lawrence D True; Aikou Okamoto; Scott L Pomeroy; Samuel Singer; Todd R Golub; Eric S Lander; Gad Getz; William R Sellers; Matthew Meyerson
Journal:  Nature       Date:  2010-02-18       Impact factor: 49.962

10.  Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.

Authors:  Richard S Maser; Bhudipa Choudhury; Peter J Campbell; Bin Feng; Kwok-Kin Wong; Alexei Protopopov; Jennifer O'Neil; Alejandro Gutierrez; Elena Ivanova; Ilana Perna; Eric Lin; Vidya Mani; Shan Jiang; Kate McNamara; Sara Zaghlul; Sarah Edkins; Claire Stevens; Cameron Brennan; Eric S Martin; Ruprecht Wiedemeyer; Omar Kabbarah; Cristina Nogueira; Gavin Histen; Jon Aster; Marc Mansour; Veronique Duke; Letizia Foroni; Adele K Fielding; Anthony H Goldstone; Jacob M Rowe; Yaoqi A Wang; A Thomas Look; Michael R Stratton; Lynda Chin; P Andrew Futreal; Ronald A DePinho
Journal:  Nature       Date:  2007-05-21       Impact factor: 49.962
  10 in total
  8 in total

1.  Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy.

Authors:  Ren-Chin Wu; Ayse Ayhan; Daichi Maeda; Kyu-Rae Kim; Blaise A Clarke; Patricia Shaw; Michael Herman Chui; Barry Rosen; Ie-Ming Shih; Tian-Li Wang
Journal:  J Pathol       Date:  2014-03       Impact factor: 7.996

Review 2.  Functional diversity and pharmacological profiles of the FKBPs and their complexes with small natural ligands.

Authors:  Andrzej Galat
Journal:  Cell Mol Life Sci       Date:  2012-12-08       Impact factor: 9.261

3.  Intratumoral diversity of telomere length in individual neuroblastoma tumors.

Authors:  Annalisa Pezzolo; Angela Pistorio; Claudio Gambini; Riccardo Haupt; Manuela Ferraro; Giovanni Erminio; Bruno De Bernardi; Alberto Garaventa; Vito Pistoia
Journal:  Oncotarget       Date:  2015-04-10

4.  TERT promoter mutations and telomere length in adult malignant gliomas and recurrences.

Authors:  Barbara Heidenreich; P Sivaramakrishna Rachakonda; Ismail Hosen; Florian Volz; Kari Hemminki; Astrid Weyerbrock; Rajiv Kumar
Journal:  Oncotarget       Date:  2015-04-30

Review 5.  Evolving concepts of tumor heterogeneity.

Authors:  Victoria R Zellmer; Siyuan Zhang
Journal:  Cell Biosci       Date:  2014-11-25       Impact factor: 7.133

6.  Reduced sperm telomere length in individuals with varicocele is associated with reduced genomic integrity.

Authors:  Sahar Tahamtan; Marziyeh Tavalaee; Tayebeh Izadi; Nooshin Barikrow; Zahra Zakeri; Richard A Lockshin; Homayoun Abbasi; Mohammad Hosseini Nasr-Esfahani
Journal:  Sci Rep       Date:  2019-03-13       Impact factor: 4.379

7.  The telomere maintenance mechanism spectrum and its dynamics in gliomas.

Authors:  Sojin Kim; Tamrin Chowdhury; Hyeon Jong Yu; Jee Ye Kahng; Chae Eun Lee; Seung Ah Choi; Kyung-Min Kim; Ho Kang; Joo Ho Lee; Soon-Tae Lee; Jae-Kyung Won; Kyung Hyun Kim; Min-Sung Kim; Ji Yeoun Lee; Jin Wook Kim; Yong-Hwy Kim; Tae Min Kim; Seung Hong Choi; Ji Hoon Phi; Young-Kyoung Shin; Ja-Lok Ku; Sungyoung Lee; Hongseok Yun; Hwajin Lee; Dokyoung Kim; Kyoungmi Kim; Junho K Hur; Sung-Hye Park; Seung-Ki Kim; Chul-Kee Park
Journal:  Genome Med       Date:  2022-08-11       Impact factor: 15.266

Review 8.  Integration of Telomere Length Dynamics into Systems Biology Framework: A Review.

Authors:  Lilit Nersisyan
Journal:  Gene Regul Syst Bio       Date:  2016-06-16
  8 in total

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