| Literature DB >> 22340490 |
Jennifer B Long1, David Van Vactor.
Abstract
Dominant VAPB mutations are implicated in neurodegenerative disease, including amyotrophic lateral sclerosis and spinal muscular atrophy. In the current issue, Han et al. (2012) uncover a mechanism through which the secreted VAPB MSP domain regulates actin organization and mitochondrial function in muscle cells through LAR and Robo receptor activation.Entities:
Year: 2012 PMID: 22340490 PMCID: PMC3601526 DOI: 10.1016/j.devcel.2012.01.021
Source DB: PubMed Journal: Dev Cell ISSN: 1534-5807 Impact factor: 12.270