Literature DB >> 2233985

The effect of mycophenolic acid on the cell cycle of Candida albicans.

C M Quinn1, V C Bugeja, J A Gallagher, P A Whittaker.   

Abstract

Mycophenolic acid inhibited the growth of Candida albicans. Cultures exposed to a concentration of 8.4 micrograms ml-1 mycophenolic acid were found to exhibit cell cycle arrest with two or more buds. Nuclear staining revealed that these were nucleate implying a possible defect in cytokinesis. The results are discussed in relation to the possible mode of action of mycophenolic acid.

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Year:  1990        PMID： 2233985     DOI： 10.1007/bf02282799

Source DB:  PubMed          Journal:  Mycopathologia        ISSN： 0301-486X            Impact factor:   2.574


  11 in total

1.  Studies in the biochemistry of micro-organisms: The metabolic products of the Penicillium brevi-compactum series.

Authors:  P W Clutterbuck; A E Oxford; H Raistrick; G Smith
Journal:  Biochem J       Date:  1932       Impact factor: 3.857

2.  Antitumor activity of mycophenolic acid.

Authors:  S Suzuki; T Kimura; K Ando; M Sawada; G Tamura
Journal:  J Antibiot (Tokyo)       Date:  1969-07       Impact factor: 2.649

3.  Antiviral activity of mycophenolic acid. Studies on antiviral and antitumor antibiotics. IV.

Authors:  K Ando; S Suzuki; G Tamura; K Arima
Journal:  J Antibiot (Tokyo)       Date:  1968-11       Impact factor: 2.649

4.  Mycophenolic acid: antiviral and antitumor properties.

Authors:  R H Williams; D H Lively; D C DeLong; J C Cline; M J Sweeny
Journal:  J Antibiot (Tokyo)       Date:  1968-07       Impact factor: 2.649

5.  Some biological properties of mycophenolic acid.

Authors:  T Noto; M Sawada; K Ando; K Koyama
Journal:  J Antibiot (Tokyo)       Date:  1969-04       Impact factor: 2.649

6.  Mycophenolic acid: an anti-cancer compound with unusual properties.

Authors:  S B Carter; T J Franklin; D F Jones; B J Leonard; S D Mills; R W Turner; W B Turner
Journal:  Nature       Date:  1969-08-23       Impact factor: 49.962

7.  Metabolism and biochemistry of mycophenolic acid.

Authors:  M J Sweeney; D H Hoffman; M A Esterman
Journal:  Cancer Res       Date:  1972-09       Impact factor: 12.701

8.  Mycophenolic acid in psoriasis.

Authors:  S Spatz; A Rudnicka; C J McDonald
Journal:  Br J Dermatol       Date:  1978-04       Impact factor: 9.302

9.  In vitro antiviral activity of mycophenolic acid and its reversal by guanine-type compounds.

Authors:  J C Cline; J D Nelson; K Gerzon; R H Williams; D C Delong
Journal:  Appl Microbiol       Date:  1969-07

10.  The inhibition of nucleic acid synthesis by mycophenolic acid.

Authors:  T J Franklin; J M Cook
Journal:  Biochem J       Date:  1969-07       Impact factor: 3.857
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  3 in total

Review 1.  The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors.

Authors:  L Hedstrom; G Liechti; J B Goldberg; D R Gollapalli
Journal:  Curr Med Chem       Date:  2011       Impact factor: 4.530

2.  Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid.

Authors:  G A Köhler; T C White; N Agabian
Journal:  J Bacteriol       Date:  1997-04       Impact factor: 3.490

3.  Virtual high-throughput screening identifies mycophenolic acid as a novel RNA capping inhibitor.

Authors:  Maude Tremblay-Létourneau; Simon Despins; Isabelle Bougie; Martin Bisaillon
Journal:  PLoS One       Date:  2011-09-15       Impact factor: 3.240
  3 in total

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