BACKGROUND: Despite advances in therapy, sepsis still has a high mortality rate. To improve the treatment outcome, early diagnosis and treatment is essential, as reflected in many publications about biomarkers for sepsis. Recent models of automatic cell analyzers provide the delta neutrophil index (DN), which corresponds to the fraction of immature granulocytes in circulating blood. This study investigated DN as a prognostic marker in patients with bacteraemia. METHODS: We retrospectively collected data on adult patients with bacteraemia admitted to an urban hospital between November 2009 and April 2010. The DN was measured at the onset of bacteraemia and at 24 and 72 h later. Factors associated with 28-day mortality were assessed using logistic regression. RESULTS: A total of 102 patients were included in the analysis, and 24 patients died within 28 days. In the univariate analysis, appropriate antibiotic treatment, multidrug-resistant bacterial infection, history of intensive care unit (ICU) stay before the onset of bacteraemia, healthcare-associated infection, DN at 72 h after the onset of bacteraemia (DN-72 h), and platelet count at the onset of bacteraemia were significantly associated with survival. In multivariate analysis, DN-72 h (odds ratio (OR) 1.246, 95% confidence interval (CI) 1.030-1.508; p = 0.023), platelet count at the onset of bacteraemia (OR 0.986, 95% CI 0.977-0.995; p = 0.003), and history of ICU stay before the onset of bacteraemia (OR 4.907, 95% CI 1.045-23.051; p = 0.044) were the independent factors associated with survival. CONCLUSION: DN at 72 h after bacteraemia may be valuable to assess the prognosis of patients with bacteraemia.
BACKGROUND: Despite advances in therapy, sepsis still has a high mortality rate. To improve the treatment outcome, early diagnosis and treatment is essential, as reflected in many publications about biomarkers for sepsis. Recent models of automatic cell analyzers provide the delta neutrophil index (DN), which corresponds to the fraction of immature granulocytes in circulating blood. This study investigated DN as a prognostic marker in patients with bacteraemia. METHODS: We retrospectively collected data on adult patients with bacteraemia admitted to an urban hospital between November 2009 and April 2010. The DN was measured at the onset of bacteraemia and at 24 and 72 h later. Factors associated with 28-day mortality were assessed using logistic regression. RESULTS: A total of 102 patients were included in the analysis, and 24 patients died within 28 days. In the univariate analysis, appropriate antibiotic treatment, multidrug-resistant bacterial infection, history of intensive care unit (ICU) stay before the onset of bacteraemia, healthcare-associated infection, DN at 72 h after the onset of bacteraemia (DN-72 h), and platelet count at the onset of bacteraemia were significantly associated with survival. In multivariate analysis, DN-72 h (odds ratio (OR) 1.246, 95% confidence interval (CI) 1.030-1.508; p = 0.023), platelet count at the onset of bacteraemia (OR 0.986, 95% CI 0.977-0.995; p = 0.003), and history of ICU stay before the onset of bacteraemia (OR 4.907, 95% CI 1.045-23.051; p = 0.044) were the independent factors associated with survival. CONCLUSION: DN at 72 h after bacteraemia may be valuable to assess the prognosis of patients with bacteraemia.
Authors: Jae Hyon Park; Hyeong Ju Byeon; Keum Hwa Lee; Jong Wook Lee; Andreas Kronbichler; Michael Eisenhut; Jae Il Shin Journal: Inflamm Res Date: 2017-06-23 Impact factor: 4.575
Authors: Sang Hun Lee; Kyung Ok Ko; Jae Woo Lim; Jung Min Yoon; Young Hwa Song; Jong Wook Lee; Eun Jung Cheon Journal: Rheumatol Int Date: 2019-09-23 Impact factor: 2.631
Authors: Hye Won Kim; Ji Hyun Yoon; Sung Joon Jin; Sun Bean Kim; Nam Su Ku; Su Jin Jeong; Sang Hoon Han; Jun Yong Choi; June Myung Kim; Young Goo Song Journal: Infect Chemother Date: 2014-06-20
Authors: Ho Young Yune; Sung Phil Chung; Yoo Seok Park; Hyun Soo Chung; Hye Sun Lee; Jong Wook Lee; Jong Woo Park; Je Sung You; Incheol Park; Hahn Shick Lee Journal: PLoS One Date: 2015-03-23 Impact factor: 3.240
Authors: Dong Hyuk Shin; Young Suk Cho; Gyu Chong Cho; Hee Cheol Ahn; Seung Min Park; Seung Wook Lim; Young Taeck Oh; Ji Woong Cho; Sang O Park; Young Hwan Lee Journal: World J Emerg Surg Date: 2017-07-24 Impact factor: 5.469
Authors: Tae Seop Lim; Beom Kyung Kim; Jong Wook Lee; Young Ki Lee; Sooyun Chang; Seung Up Kim; Do Young Kim; Sang Hoon Ahn; Kwang-Hyub Han; Chae Yoon Chon; Jun Yong Park Journal: PLoS One Date: 2014-01-23 Impact factor: 3.240