OBJECTIVES: The aim of study was to determine the presence of some of the herpesviruses including herpes simplex virus (HSV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in adenoid tissues of children with adenoid hypertrophy (AH) and chronic adenoiditis (CA) and to investigate the potential role of the herpesviruses in patogenesis of AH and CA. PATIENTS AND METHODS: A total of 72 patients (41 boys, 31 girls; mean age 4 years and 2 months; range 2 to 9 years) who underwent adenoidectomy or adenotonsillectomy (with or without placement of a ventilation tube) in our clinic between October 2007 and May 2008, were included. The patients were divided into two groups, as AH group (n=42) and the CA group (n=30). Adenoid tissues collected from patients in both groups were analyzed by polymerase chain reaction (PCR) for the presence of HSV, EBV and CMV-DNA. RESULTS: The results of the PCR indicated that 33.3% in the AH group and 36.6% in the CA group were herpesvirus DNA positive. Among the herpesviruses studied, HSV-DNA was detected at the highest level (14.2% and 16.6%, respectively) in both groups, although the difference between the groups was not significant. EBV-DNA positiveness was 11.9% and CMV-DNA was 4.7% in the AH group, whereas, EBV-DNA positiveness was 13.3% and CMV-DNA was 6.6% in the CA group. CONCLUSION: Herpesviruses were determined at a high rate in adenoid tissue of children with AH and CA, suggesting that there may be a potential relationship between the presence of herpesviruses and occurrence of AH and CA in children. However, more extensive studies are required to elucidate the role of herpesviruses in the pathogenesis of AH or CA.
OBJECTIVES: The aim of study was to determine the presence of some of the herpesviruses including herpes simplex virus (HSV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in adenoid tissues of children with adenoid hypertrophy (AH) and chronic adenoiditis (CA) and to investigate the potential role of the herpesviruses in patogenesis of AH and CA. PATIENTS AND METHODS: A total of 72 patients (41 boys, 31 girls; mean age 4 years and 2 months; range 2 to 9 years) who underwent adenoidectomy or adenotonsillectomy (with or without placement of a ventilation tube) in our clinic between October 2007 and May 2008, were included. The patients were divided into two groups, as AH group (n=42) and the CA group (n=30). Adenoid tissues collected from patients in both groups were analyzed by polymerase chain reaction (PCR) for the presence of HSV, EBV and CMV-DNA. RESULTS: The results of the PCR indicated that 33.3% in the AH group and 36.6% in the CA group were herpesvirus DNA positive. Among the herpesviruses studied, HSV-DNA was detected at the highest level (14.2% and 16.6%, respectively) in both groups, although the difference between the groups was not significant. EBV-DNA positiveness was 11.9% and CMV-DNA was 4.7% in the AH group, whereas, EBV-DNA positiveness was 13.3% and CMV-DNA was 6.6% in the CA group. CONCLUSION: Herpesviruses were determined at a high rate in adenoid tissue of children with AH and CA, suggesting that there may be a potential relationship between the presence of herpesviruses and occurrence of AH and CA in children. However, more extensive studies are required to elucidate the role of herpesviruses in the pathogenesis of AH or CA.
Authors: Henrique Prestes Miramontes; Djalma José Fagundes; Julia Coelho Lima E Jurgielewicz; Haroldo Prestes Miramontes Neto; Renan Gianotto de Oliveira; Gustavo Gianotto de Oliveira; Maria Rosa Machado de Souza Journal: Int Arch Otorhinolaryngol Date: 2014-05-15
Authors: Howard Faden; Vincent Callanan; Michael Pizzuto; Mark Nagy; Mark Wilby; Daryl Lamson; Brian Wrotniak; Stefan Juretschko; Kirsten St George Journal: Int J Pediatr Otorhinolaryngol Date: 2016-09-14 Impact factor: 1.675
Authors: Mariana C Leal; Danielle Seabra Ramos; Thiago Pinto Bezerra; Ana Elizabeth S C Vilela; Rebeka Jacques de F Maciel; Mirella Rodrigues; Mariana Lira; Karen Pena de Souza Cavalcanti; Vanessa Van der Linden; Marli T Cordeiro; Demócrito Miranda; Ricardo Ximenes; Elizabeth B Brickley; Silvio S Caldas Journal: Viruses Date: 2021-01-05 Impact factor: 5.048
Authors: Iuliia Lomaeva; Anna Aghajanyan; Liudmila Dzhaparidze; Olga Borisovna Gigani; Leila V Tskhovrebova; Olga Olegovna Gigani; Valentin I Popadyuk Journal: Life (Basel) Date: 2022-02-10