BACKGROUND: The overall risk of hemolytic transfusion reactions (HTRs) from plasma (minor)-incompatible platelet (PLT) transfusions and the role of a critical anti-A or anti-B titer in predicting and preventing these reactions has not been clearly established. STUDY DESIGN AND METHODS: We evaluated all apheresis PLT (AP) transfusions for 3 months. Using the gel titer method, we determined the anti-A and/or the anti-B immunoglobulin (Ig)G titer for all incompatible APs. Reported febrile transfusion reactions and HTRs were recorded; transfusions were not prospectively evaluated by the study team. A posttransfusion direct antiglobulin test (DAT) and eluate were performed after a reported febrile or hemolytic reaction for patients who received plasma-incompatible APs. RESULTS: A total of 647 of 4288 AP transfusions (15.1%) were plasma incompatible. Group O APs (n = 278) had significantly higher anti-A and anti-B titers than group A or B APs (p < 0.0001). No group A or B APs had a titer of more than 128 (0/342). For group O APs, 73 had titers of 256 or greater (26.3%), and 27 had titers of 512 or greater (9.7%). No HTRs were reported to any plasma-incompatible AP transfusion during the study period. Two plasma-incompatible AP transfusions were associated with fever and chills and positive DATs, of which one had a positive eluate. The incidence of a DAT and eluate-positive febrile transfusion reaction in the plasma-incompatible AP population is 0.15% (95% confidence interval, 0.0%-0.86%). CONCLUSION: A critical anti-A or -B titer is not sufficient to predict the risk of hemolysis in patients receiving plasma-incompatible APs, although underreporting of reactions to the blood bank may limit the generalizability of this study.
BACKGROUND: The overall risk of hemolytic transfusion reactions (HTRs) from plasma (minor)-incompatible platelet (PLT) transfusions and the role of a critical anti-A or anti-B titer in predicting and preventing these reactions has not been clearly established. STUDY DESIGN AND METHODS: We evaluated all apheresis PLT (AP) transfusions for 3 months. Using the gel titer method, we determined the anti-A and/or the anti-B immunoglobulin (Ig)G titer for all incompatible APs. Reported febrile transfusion reactions and HTRs were recorded; transfusions were not prospectively evaluated by the study team. A posttransfusion direct antiglobulin test (DAT) and eluate were performed after a reported febrile or hemolytic reaction for patients who received plasma-incompatible APs. RESULTS: A total of 647 of 4288 AP transfusions (15.1%) were plasma incompatible. Group O APs (n = 278) had significantly higher anti-A and anti-B titers than group A or B APs (p < 0.0001). No group A or B APs had a titer of more than 128 (0/342). For group O APs, 73 had titers of 256 or greater (26.3%), and 27 had titers of 512 or greater (9.7%). No HTRs were reported to any plasma-incompatible AP transfusion during the study period. Two plasma-incompatible AP transfusions were associated with fever and chills and positive DATs, of which one had a positive eluate. The incidence of a DAT and eluate-positive febrile transfusion reaction in the plasma-incompatible AP population is 0.15% (95% confidence interval, 0.0%-0.86%). CONCLUSION: A critical anti-A or -B titer is not sufficient to predict the risk of hemolysis in patients receiving plasma-incompatible APs, although underreporting of reactions to the blood bank may limit the generalizability of this study.
Authors: J de Wildt-Eggen; S Nauta; J G Schrijver; M van Marwijk Kooy; M Bins; H C van Prooijen Journal: Transfusion Date: 2000-04 Impact factor: 3.157
Authors: Dorothy Stainsby; Hilary Jones; Deborah Asher; Claire Atterbury; Aysha Boncinelli; Lisa Brant; Catherine E Chapman; Katy Davison; Rebecca Gerrard; Alexandra Gray; Susan Knowles; Elizabeth M Love; Clare Milkins; D Brian L McClelland; Derek R Norfolk; Kate Soldan; Clare Taylor; John Revill; Lorna M Williamson; Hannah Cohen Journal: Transfus Med Rev Date: 2006-10
Authors: Aaron A R Tobian; Alice K Fuller; Kristin Uglik; Daniel J Tisch; Prabhakar D Borge; Richard J Benjamin; Paul M Ness; Karen E King Journal: Transfusion Date: 2013-11-19 Impact factor: 3.157
Authors: Martin D Zielinski; Jason J Schrager; Pamela Johnson; James R Stubbs; Stephanie Polites; Scott P Zietlow; Donald H Jenkins; Bryce R H Robinson Journal: Clin Transl Sci Date: 2014-09-09 Impact factor: 4.689
Authors: Martin D Zielinski; Dustin L Smoot; James R Stubbs; Donald H Jenkins; Myung S Park; Scott P Zietlow Journal: Transfusion Date: 2013-01 Impact factor: 3.337