AIM: The ability of nanoparticles to form larger superstructures of aggregates and agglomerates has been extensively noted in the literature. The in vivo biological impact of these structures, however, has not been assessed. This knowledge gap is especially critical in the safety assessment of nanoparticles to be used for therapeutic purposes. METHOD/ RESULTS: Here we show that when administered intravenously into a mouse model, gold nanoparticle superstructures of reversible agglomerates and irreversible aggregates demonstrate significant differences in organ and cellular distribution compared with the primary particle building blocks. In addition, different structures produced different blood serum chemistry data. CONCLUSION: These findings raise the possibility for different mechanisms of toxicity between the structures. Such a possibility necessitates complete characterization and stability assessment of nanomaterials prior to their in vivo administration.
AIM: The ability of nanoparticles to form larger superstructures of aggregates and agglomerates has been extensively noted in the literature. The in vivo biological impact of these structures, however, has not been assessed. This knowledge gap is especially critical in the safety assessment of nanoparticles to be used for therapeutic purposes. METHOD/ RESULTS: Here we show that when administered intravenously into a mouse model, gold nanoparticle superstructures of reversible agglomerates and irreversible aggregates demonstrate significant differences in organ and cellular distribution compared with the primary particle building blocks. In addition, different structures produced different blood serum chemistry data. CONCLUSION: These findings raise the possibility for different mechanisms of toxicity between the structures. Such a possibility necessitates complete characterization and stability assessment of nanomaterials prior to their in vivo administration.
Authors: Sheetal R D'Mello; Celia N Cruz; Mei-Ling Chen; Mamta Kapoor; Sau L Lee; Katherine M Tyner Journal: Nat Nanotechnol Date: 2017-04-24 Impact factor: 39.213
Authors: Iwona Cicha; Cédric Chauvierre; Isabelle Texier; Claudia Cabella; Josbert M Metselaar; János Szebeni; László Dézsi; Christoph Alexiou; François Rouzet; Gert Storm; Erik Stroes; Donald Bruce; Neil MacRitchie; Pasquale Maffia; Didier Letourneur Journal: Cardiovasc Res Date: 2018-11-01 Impact factor: 10.787
Authors: James L Weaver; Grainne A Tobin; Taylor Ingle; Simona Bancos; David Stevens; Rodney Rouse; Kristina E Howard; David Goodwin; Alan Knapton; Xiaohong Li; Katherine Shea; Sharron Stewart; Lin Xu; Peter L Goering; Qin Zhang; Paul C Howard; Jessie Collins; Saeed Khan; Kidon Sung; Katherine M Tyner Journal: Part Fibre Toxicol Date: 2017-07-17 Impact factor: 9.400