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Literature DB >> 22337738

Is carbamazepine safe to take during pregnancy?

Abstract

QUESTION: Some of my pregnant patients are afraid to take their antiepileptic drugs during pregnancy because of the known risk of malformations and the neurodevelopmental problems associated with valproic acid. Are there similar concerns with carbamazepine? ANSWER: Similar to valproic acid, carbamazepine increases the risk of neural tube defects; however, it does not increase the risk of other malformations. Carbamazepine is also not associated with an increased risk of developmental delay.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2012 PMID： 22337738 PMCID： PMC3279268

Source DB: PubMed Journal: Can Fam Physician ISSN： 0008-350X Impact factor: 3.275

14 in total

1. Antiepileptic drug regimens and major congenital abnormalities in the offspring.

Authors: E B Samrén; C M van Duijn; G C Christiaens; A Hofman; D Lindhout
Journal: Ann Neurol Date: 1999-11 Impact factor: 10.422

2. Major malformations in offspring of women with epilepsy.

Authors: Erja Kaaja; Risto Kaaja; Vilho Hiilesmaa
Journal: Neurology Date: 2003-02-25 Impact factor: 9.910

3. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register.

Authors: J Morrow; A Russell; E Guthrie; L Parsons; I Robertson; R Waddell; B Irwin; R C McGivern; P J Morrison; J Craig
Journal: J Neurol Neurosurg Psychiatry Date: 2005-09-12 Impact factor: 10.154

Review 4. Consensus guidelines: preconception counseling, management, and care of the pregnant woman with epilepsy.

Authors: A V Delgado-Escueta; D Janz
Journal: Neurology Date: 1992-04 Impact factor: 9.910

5. Maternal epilepsy and abnormalities of the fetus and newborn.

Authors: B D Speidel; S R Meadow
Journal: Lancet Date: 1972-10-21 Impact factor: 79.321

6. Language skills of school-aged children prenatally exposed to antiepileptic drugs.

Authors: C Nadebaum; V A Anderson; F Vajda; D C Reutens; S Barton; A G Wood
Journal: Neurology Date: 2011-02-22 Impact factor: 9.910

Review 7. Epileptic disorders in pregnancy: an overview.

Authors: Cynthia L Harden; Nitin K Sethi
Journal: Curr Opin Obstet Gynecol Date: 2008-12 Impact factor: 1.927

8. Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.

Authors: Kimford J Meador; Gus A Baker; Nancy Browning; Jill Clayton-Smith; Deborah T Combs-Cantrell; Morris Cohen; Laura A Kalayjian; Andres Kanner; Joyce D Liporace; Page B Pennell; Michael Privitera; David W Loring
Journal: N Engl J Med Date: 2009-04-16 Impact factor: 91.245

Review 9. Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications.

Authors: Yusuf Cem Kaplan; Omer Demir
Journal: Curr Neuropharmacol Date: 2021 Impact factor: 7.708

10. Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review.

Authors: Sarah J Nevitt; Anthony G Marson; Catrin Tudur Smith
Journal: Cochrane Database Syst Rev Date: 2018-10-24

Is carbamazepine safe to take during pregnancy?

1. Antiepileptic drug regimens and major congenital abnormalities in the offspring.

2. Major malformations in offspring of women with epilepsy.

3. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register.

Review 4. Consensus guidelines: preconception counseling, management, and care of the pregnant woman with epilepsy.

5. Maternal epilepsy and abnormalities of the fetus and newborn.

6. Language skills of school-aged children prenatally exposed to antiepileptic drugs.

Review 7. Epileptic disorders in pregnancy: an overview.

8. Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.

Review 9. Antiepileptic drugs as human teratogens.

Review 10. Spina bifida in infants of women treated with carbamazepine during pregnancy.

1. Topiramate versus carbamazepine monotherapy for epilepsy: an individual participant data review.

2. Drug use and/or exposure in pregnancy: Presence of risk versus quantity of risk.

Review 3. Topiramate versus carbamazepine monotherapy for epilepsy: an individual participant data review.

Review 4. Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review.

Review 5. Lamotrigine versus carbamazepine monotherapy for epilepsy: an individual participant data review.

Review 6. Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review.

7. Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review.

Review 8. Lamotrigine versus carbamazepine monotherapy for epilepsy: an individual participant data review.

Review 9. Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications.

10. Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review.