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Literature DB >> 2233731

Manipulations of cholinesterase gene expression modulate murine megakaryocytopoiesis in vitro.

D Patinkin¹, S Seidman, F Eckstein, F Benseler, H Zakut, H Soreq.

Abstract

Megakaryocytopoiesis was selectively inhibited in cultured murine bone marrow cells by a 15-mer oligodeoxynucleotide complementary to the initiator AUG region in butyrylcholinesterase mRNA. Furthermore, conditioned medium from Xenopus oocytes producing recombinant butyrylcholinesterase stimulated megakaryocytopoiesis. These observations implicate butyrylcholinesterase in megakaryocytopoiesis and suggest application of oligodeoxynucleotides for modulating bone marrow development.

Entities: Gene Species

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Year: 1990 PMID： 2233731 PMCID： PMC361403 DOI： 10.1128/mcb.10.11.6046-6050.1990

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

26 in total

Review 1. Regulators of thrombopoiesis: their biochemistry and physiology.

Authors: R J Hill; J Levin
Journal: Blood Cells Date: 1989

2. Evidence for a novel growth factor in Xenopus oocytes.

Authors: C Théry; P Jullien; D A Lawrence
Journal: Biochem Biophys Res Commun Date: 1989-04-28 Impact factor: 3.575

3. Effect of recombinant and purified hematopoietic growth factors on human megakaryocyte colony formation.

Authors: E Bruno; R Briddell; R Hoffman
Journal: Exp Hematol Date: 1988-06 Impact factor: 3.084

4. Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro.

Authors: T Ishibashi; H Kimura; T Uchida; S Kariyone; P Friese; S A Burstein
Journal: Proc Natl Acad Sci U S A Date: 1989-08 Impact factor: 11.205

5. Expression and tissue-specific assembly of human butyrylcholine esterase in microinjected Xenopus laevis oocytes.

Authors: H Soreq; S Seidman; P A Dreyfus; D Zevin-Sonkin; H Zakut
Journal: J Biol Chem Date: 1989-06-25 Impact factor: 5.157

6. Coamplification of human acetylcholinesterase and butyrylcholinesterase genes in blood cells: correlation with various leukemias and abnormal megakaryocytopoiesis.

Authors: Y Lapidot-Lifson; C A Prody; D Ginzberg; D Meytes; H Zakut; H Soreq
Journal: Proc Natl Acad Sci U S A Date: 1989-06 Impact factor: 11.205

Review 7. Oligodeoxynucleotides as inhibitors of gene expression: a review.

Authors: C A Stein; J S Cohen
Journal: Cancer Res Date: 1988-05-15 Impact factor: 12.701

8. Multiple levels of regulation of megakaryocytopoiesis.

Authors: N Williams; H Jackson; F Walker; S H Oon
Journal: Blood Cells Date: 1989

9. Specific inhibition of cell-surface T-cell receptor expression by antisense oligodeoxynucleotides and its effect on the production of an antigen-specific regulatory T-cell factor.

Authors: H Zheng; B M Sahai; P Kilgannon; A Fotedar; D R Green
Journal: Proc Natl Acad Sci U S A Date: 1989-05 Impact factor: 11.205

10. Inhibition of human megakaryocytopoiesis in vitro by platelet factor 4 (PF4) and a synthetic COOH-terminal PF4 peptide.

Authors: A M Gewirtz; B Calabretta; B Rucinski; S Niewiarowski; W Y Xu
Journal: J Clin Invest Date: 1989-05 Impact factor: 14.808

8 in total

1. N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis.

Authors: B Velan; C Kronman; A Ordentlich; Y Flashner; M Leitner; S Cohen; A Shafferman
Journal: Biochem J Date: 1993-12-15 Impact factor: 3.857

Review 2. Natural inhibitors of cholinesterases: implications for adverse drug reactions.

Authors: M D Krasowski; D S McGehee; J Moss
Journal: Can J Anaesth Date: 1997-05 Impact factor: 5.063

3. The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7.

Authors: D K Getman; J H Eubanks; S Camp; G A Evans; P Taylor
Journal: Am J Hum Genet Date: 1992-07 Impact factor: 11.025

4. Antisense oligonucleotide inhibition of acetylcholinesterase gene expression induces progenitor cell expansion and suppresses hematopoietic apoptosis ex vivo.

Authors: H Soreq; D Patinkin; E Lev-Lehman; M Grifman; D Ginzberg; F Eckstein; H Zakut
Journal: Proc Natl Acad Sci U S A Date: 1994-08-16 Impact factor: 11.205

5. Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis.

Authors: Y Lapidot-Lifson; D Patinkin; C A Prody; G Ehrlich; S Seidman; R Ben-Aziz; F Benseler; F Eckstein; H Zakut; H Soreq
Journal: Proc Natl Acad Sci U S A Date: 1992-01-15 Impact factor: 11.205

6. Antisense inhibition of butyrylcholinesterase gene expression predicts adverse hematopoietic consequences to cholinesterase inhibitors.

Authors: D Patinkin; E Lev-Lehman; H Zakut; F Eckstein; H Soreq
Journal: Cell Mol Neurobiol Date: 1994-10 Impact factor: 5.046

7. The role of Jun transcription factor expression and phosphorylation in neuronal differentiation, neuronal cell death, and plastic adaptations in vivo.

Authors: K H Schlingensiepen; F Wollnik; M Kunst; R Schlingensiepen; T Herdegen; W Brysch
Journal: Cell Mol Neurobiol Date: 1994-10 Impact factor: 5.046

8. Intramolecular relationships in cholinesterases revealed by oocyte expression of site-directed and natural variants of human BCHE.

Authors: L F Neville; A Gnatt; Y Loewenstein; S Seidman; G Ehrlich; H Soreq
Journal: EMBO J Date: 1992-04 Impact factor: 11.598

8 in total