BACKGROUND: Structural brain abnormalities have been demonstrated in subjects with BPD in prefrontal and fronto-limbic regions involved in the regulation of emotion and impulsive behavior, executive cognitive function and episodic memory. Impairment in these cognitive functions is associated with increased vulnerability to suicidal behavior. We compared BPD suicide attempters and non-attempters, high and low lethality attempters to healthy controls to identify neural circuits associated with suicidal behavior in BPD. METHODS: Structural MRI scans were obtained on 68 BPD subjects (16 male, 52 female), defined by IPDE and DIB/R criteria, and 52 healthy controls (HC: 28 male, 24 female). Groups were compared by diagnosis, attempt status, and attempt lethality. ROIs were defined for areas reported to have structural or metabolic abnormalities in BPD, and included: mid-inf. orbitofrontal cortex, mid-sup temporal cortex, anterior cingulate, insula, hippocampus, amygdala, fusiform, lingual and parahippocampal gyri. Data were analyzed using optimized voxel-based morphometry implemented with DARTEL in SPM5, co-varied for age and gender, corrected for cluster extent (p < .001). RESULTS: Compared to HC, BPD attempters had significantly diminished gray matter concentrations in 8 of 9 ROIs, non-attempters in 5 of 9 ROIs. Within the BPD sample, attempters had diminished gray matter in Lt. insula compared to non-attempters. High lethality attempters had significant decreases in Rt. mid-sup. temporal gyrus, Rt. mid-inf. orbitofrontal gyrus, Rt. insular cortex, Lt. fusiform gyrus, Lt. lingual gyrus and Rt. parahippocampal gyrus compared to low lethality attempters. CONCLUSIONS: Specific structural abnormalities discriminate BPD attempters from non-attempters and high from low lethality attempters. Copyright Â
BACKGROUND:Structural brain abnormalities have been demonstrated in subjects with BPD in prefrontal and fronto-limbic regions involved in the regulation of emotion and impulsive behavior, executive cognitive function and episodic memory. Impairment in these cognitive functions is associated with increased vulnerability to suicidal behavior. We compared BPD suicide attempters and non-attempters, high and low lethality attempters to healthy controls to identify neural circuits associated with suicidal behavior in BPD. METHODS: Structural MRI scans were obtained on 68 BPD subjects (16 male, 52 female), defined by IPDE and DIB/R criteria, and 52 healthy controls (HC: 28 male, 24 female). Groups were compared by diagnosis, attempt status, and attempt lethality. ROIs were defined for areas reported to have structural or metabolic abnormalities in BPD, and included: mid-inf. orbitofrontal cortex, mid-sup temporal cortex, anterior cingulate, insula, hippocampus, amygdala, fusiform, lingual and parahippocampal gyri. Data were analyzed using optimized voxel-based morphometry implemented with DARTEL in SPM5, co-varied for age and gender, corrected for cluster extent (p < .001). RESULTS: Compared to HC, BPD attempters had significantly diminished gray matter concentrations in 8 of 9 ROIs, non-attempters in 5 of 9 ROIs. Within the BPD sample, attempters had diminished gray matter in Lt. insula compared to non-attempters. High lethality attempters had significant decreases in Rt. mid-sup. temporal gyrus, Rt. mid-inf. orbitofrontal gyrus, Rt. insular cortex, Lt. fusiform gyrus, Lt. lingual gyrus and Rt. parahippocampal gyrus compared to low lethality attempters. CONCLUSIONS: Specific structural abnormalities discriminate BPD attempters from non-attempters and high from low lethality attempters. Copyright Â
Authors: Vaibhav A Diwadkar; Sunali Wadehra; Patrick Pruitt; Matcheri S Keshavan; Usha Rajan; Caroline Zajac-Benitez; Simon B Eickhoff Journal: Arch Gen Psychiatry Date: 2012-03
Authors: Paul H Soloff; Carolyn Cidis Meltzer; Carl Becker; Phil J Greer; Doreen Constantine Journal: Psychiatry Res Date: 2005-04-30 Impact factor: 3.222
Authors: Harold W Koenigsberg; Larry J Siever; Hedok Lee; Scott Pizzarello; Antonia S New; Marianne Goodman; Hu Cheng; Janine Flory; Isak Prohovnik Journal: Psychiatry Res Date: 2009-04-24 Impact factor: 3.222
Authors: Maria A Oquendo; Giovanni P A Placidi; Kevin M Malone; Carl Campbell; John Keilp; Beth Brodsky; Lawrence S Kegeles; Thomas B Cooper; Ramin V Parsey; Ronald L van Heertum; J John Mann Journal: Arch Gen Psychiatry Date: 2003-01
Authors: Jennifer A Silvers; Alexa D Hubbard; Sadia Chaudhury; Emily Biggs; Jocelyn Shu; Michael F Grunebaum; Eric Fertuck; Jochen Weber; Hedy Kober; Amanda Carson-Wong; Beth S Brodsky; Megan Chesin; Kevin N Ochsner; Barbara Stanley Journal: J Psychiatr Res Date: 2016-06-25 Impact factor: 4.791
Authors: Jessica R Gilbert; Elizabeth D Ballard; Christina S Galiano; Allison C Nugent; Carlos A Zarate Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2019-12-03
Authors: Jennifer A Y Johnston; Fei Wang; Jie Liu; Benjamin N Blond; Amanda Wallace; Jiacheng Liu; Linda Spencer; Elizabeth T Cox Lippard; Kirstin L Purves; Angeli Landeros-Weisenberger; Eric Hermes; Brian Pittman; Sheng Zhang; Robert King; Andrés Martin; Maria A Oquendo; Hilary P Blumberg Journal: Am J Psychiatry Date: 2017-01-31 Impact factor: 18.112
Authors: Christoforos I Giakoumatos; Neeraj Tandon; Jai Shah; Ian T Mathew; Roscoe O Brady; Brett A Clementz; Godfrey D Pearlson; Gunvant K Thaker; Carol A Tamminga; John A Sweeney; Matcheri S Keshavan Journal: J Psychiatr Res Date: 2013-07-15 Impact factor: 4.791