OBJECTIVE: To evaluate the predictive value of uric acid (UA) on type 2 diabetes mellitus (DM). METHODS: 711 subjects aged 45 - 60 years old with normal fasting blood glucose (FBG) were studied in 1992. The subjects were divided into 2 groups according to their 1992 UA data in the normal UA group and in the hyperuricemia (HUA) group. We analyzed the prevalence of DM-2 in 2007 according to data on UA in 1992. Relative risk (RR) of the cohort was calculated under χ(2) test and logistic regression analysis. RESULTS: FBG and the prevalence rate of DM in 2007 in the HUA group were statistically higher than those in the normal group. The relative risk (RR) of HUA to DM was 3.749 (P = 0.000), with 95% Confidence interval (CI) as 2.387 - 5.890. Data from the logistic regression analysis, after adjusting for other risk factors, the RR of UA to DM was 1.426 (P = 0.003), with 95%CI as 1.173 - 1.705. CONCLUSION: The abnormal UA was closely related to glucose metabolism disorder while hyperuricemia appeared to be associated with increased risk of type 2 DM.
OBJECTIVE: To evaluate the predictive value of uric acid (UA) on type 2 diabetes mellitus (DM). METHODS: 711 subjects aged 45 - 60 years old with normal fasting blood glucose (FBG) were studied in 1992. The subjects were divided into 2 groups according to their 1992 UA data in the normal UA group and in the hyperuricemia (HUA) group. We analyzed the prevalence of DM-2 in 2007 according to data on UA in 1992. Relative risk (RR) of the cohort was calculated under χ(2) test and logistic regression analysis. RESULTS: FBG and the prevalence rate of DM in 2007 in the HUA group were statistically higher than those in the normal group. The relative risk (RR) of HUA to DM was 3.749 (P = 0.000), with 95% Confidence interval (CI) as 2.387 - 5.890. Data from the logistic regression analysis, after adjusting for other risk factors, the RR of UA to DM was 1.426 (P = 0.003), with 95%CI as 1.173 - 1.705. CONCLUSION: The abnormal UA was closely related to glucose metabolism disorder while hyperuricemia appeared to be associated with increased risk of type 2 DM.