Wen Huang1, Hong-yuan Wang, Qi Wang. 1. Department of Toxicology, School of Public Health, Peking University, Beijing 100191, China.
Abstract
OBJECTIVE: Synthesize the relevant research and then discuss the influence of inhalable particulate matter (PM(10)) on mortality by exposure-response analysis. METHODS: The eligible research papers which studied the association between PM(10) and overall mortality of residents, the mortality of cardiovascular and cerebrovascular diseases and the mortality of respiratory diseases; and 21 pieces of the papers were adopted in this study. The papers were analyzed by Stata 9.0 software, and the exposure-response coefficient of PM(10) and mortality were extracted. The effect size was amalgamated by fixed or random effects, and the sensitivity analysis and publication bias of the results were detected and adjusted. RESULTS: Each 10 µg/m(3) increase of PM(10) was associated with estimated relative risk (RR) of daily all-course mortality, the mortality of cardiovascular and cerebrovascular diseases and the mortality of respiratory diseases at 1.0033 (95%CI: 1.0022 - 1.0044), 1.0045 (95%CI: 1.0029 - 1.0062) and 1.0056 (95%CI: 1.0033 - 1.0079), respectively. After the publication bias was adjusted, the RR of daily all-cause, cardiovascular and cerebrovascular diseases and respiratory diseases mortality was reduced to 1.0012 (95%CI: 1.0002 - 1.0022), 1.0011 (95%CI: 0.9996 - 1.0026) and 1.0023 (95%CI: 1.0001 - 1.0045). CONCLUSION: The increase of the concentration of PM(10) led to the increase of the daily all-course mortality, the mortality of cardiovascular and cerebrovascular diseases and the mortality of respiratory diseases.
OBJECTIVE: Synthesize the relevant research and then discuss the influence of inhalable particulate matter (PM(10)) on mortality by exposure-response analysis. METHODS: The eligible research papers which studied the association between PM(10) and overall mortality of residents, the mortality of cardiovascular and cerebrovascular diseases and the mortality of respiratory diseases; and 21 pieces of the papers were adopted in this study. The papers were analyzed by Stata 9.0 software, and the exposure-response coefficient of PM(10) and mortality were extracted. The effect size was amalgamated by fixed or random effects, and the sensitivity analysis and publication bias of the results were detected and adjusted. RESULTS: Each 10 µg/m(3) increase of PM(10) was associated with estimated relative risk (RR) of daily all-course mortality, the mortality of cardiovascular and cerebrovascular diseases and the mortality of respiratory diseases at 1.0033 (95%CI: 1.0022 - 1.0044), 1.0045 (95%CI: 1.0029 - 1.0062) and 1.0056 (95%CI: 1.0033 - 1.0079), respectively. After the publication bias was adjusted, the RR of daily all-cause, cardiovascular and cerebrovascular diseases and respiratory diseases mortality was reduced to 1.0012 (95%CI: 1.0002 - 1.0022), 1.0011 (95%CI: 0.9996 - 1.0026) and 1.0023 (95%CI: 1.0001 - 1.0045). CONCLUSION: The increase of the concentration of PM(10) led to the increase of the daily all-course mortality, the mortality of cardiovascular and cerebrovascular diseases and the mortality of respiratory diseases.