Literature DB >> 22335554

Sphingosine kinase: a key to solving the 'French Paradox'?

Jeremy A Hengst1, Jong K Yun.   

Abstract

A host of beneficial effects have been attributed to the red wine polyphenol, resveratrol. Foremost, among these are its anti-cancer properties. Yet, the mechanism by which resveratrol achieves these effects are unknown. In this issue of the BJP, Lim et al. report that resveratrol and its higher order oligomers inhibit sphingosine kinase 1 (SphK1). SphK1 is a key regulator of sphingolipid metabolism and alterations of this key metabolic pathway have been linked to many hyperproliferative diseases. This study identifies a target for the action of resveratrol and its higher order oligomers and opens the door to evaluation of SphK1 as a target for chemo-prevention of cancer.
© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.

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Year:  2012        PMID： 22335554      PMCID： PMC3419904          DOI： 10.1111/j.1476-5381.2012.01898.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

Review 1.  Translational aspects of sphingosine 1-phosphate biology.

Authors:  Susan Pyne; Nigel J Pyne
Journal:  Trends Mol Med       Date:  2011-04-21       Impact factor: 11.951

2.  Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.

Authors:  Andrew J Kennedy; Thomas P Mathews; Yugesh Kharel; Saundra D Field; Morgan L Moyer; James E East; Joseph D Houck; Kevin R Lynch; Timothy L Macdonald
Journal:  J Med Chem       Date:  2011-05-02       Impact factor: 7.446

Review 3.  Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond.

Authors:  Kenneth C Loh; Dianna Baldwin; Julie D Saba
Journal:  Anticancer Agents Med Chem       Date:  2011-11       Impact factor: 2.505

4.  Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth.

Authors:  Daniela Hartmann; Jessica Lucks; Sina Fuchs; Susanne Schiffmann; Yannick Schreiber; Nerea Ferreirós; Jennifer Merkens; Rolf Marschalek; Gerd Geisslinger; Sabine Grösch
Journal:  Int J Biochem Cell Biol       Date:  2012-01-02       Impact factor: 5.085

Review 5.  Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.

Authors:  Suriyan Ponnusamy; Marisa Meyers-Needham; Can E Senkal; Sahar A Saddoughi; David Sentelle; Shanmugam Panneer Selvam; Arelis Salas; Besim Ogretmen
Journal:  Future Oncol       Date:  2010-10       Impact factor: 3.404

6.  Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival.

Authors:  Keng Gat Lim; Alexander I Gray; Susan Pyne; Nigel J Pyne
Journal:  Br J Pharmacol       Date:  2012-07       Impact factor: 8.739

7.  Resveratrol improves health and survival of mice on a high-calorie diet.

Authors:  Joseph A Baur; Kevin J Pearson; Nathan L Price; Hamish A Jamieson; Carles Lerin; Avash Kalra; Vinayakumar V Prabhu; Joanne S Allard; Guillermo Lopez-Lluch; Kaitlyn Lewis; Paul J Pistell; Suresh Poosala; Kevin G Becker; Olivier Boss; Dana Gwinn; Mingyi Wang; Sharan Ramaswamy; Kenneth W Fishbein; Richard G Spencer; Edward G Lakatta; David Le Couteur; Reuben J Shaw; Placido Navas; Pere Puigserver; Donald K Ingram; Rafael de Cabo; David A Sinclair
Journal:  Nature       Date:  2006-11-01       Impact factor: 49.962

Review 8.  Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules.

Authors:  Susan Pyne; Robert Bittman; Nigel J Pyne
Journal:  Cancer Res       Date:  2011-09-22       Impact factor: 12.701
  8 in total
  3 in total

Review 1.  Neuroprotective properties and mechanisms of resveratrol in in vitro and in vivo experimental cerebral stroke models.

Authors:  Nilendra Singh; Megha Agrawal; Sylvain Doré
Journal:  ACS Chem Neurosci       Date:  2013-06-24       Impact factor: 4.418

Review 2.  Wine Flavonoids in Health and Disease Prevention.

Authors:  Iva Fernandes; Rosa Pérez-Gregorio; Susana Soares; Nuno Mateus; Victor de Freitas
Journal:  Molecules       Date:  2017-02-14       Impact factor: 4.411

3.  Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744.

Authors:  A Vislovukh; G Kratassiouk; E Porto; N Gralievska; C Beldiman; G Pinna; A El'skaya; A Harel-Bellan; B Negrutskii; I Groisman
Journal:  Br J Cancer       Date:  2013-05-21       Impact factor: 7.640
  3 in total

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