Literature DB >> 22335448

Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity.

Claudiu T Supuran.   

Abstract

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes in mammals, being involved in numerous biosynthetic processes, including gluconeogenesis, lipogenesis and ureagenesis. It has recently emerged that CA inhibitors (CAIs) targeting the mitochondrial isoforms CA VA and VB have potential as novel antiobesity drugs. This Editorial discusses the biochemical and biological rationale for the use of CAIs in the management of obesity.

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Year:  2012        PMID： 22335448     DOI： 10.1517/14728214.2012.664132

Source DB:  PubMed          Journal:  Expert Opin Emerg Drugs        ISSN： 1472-8214            Impact factor:   4.191


  10 in total

1.  New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII.

Authors:  Rita Meleddu; Simona Distinto; Filippo Cottiglia; Rossella Angius; Pierluigi Caboni; Andrea Angeli; Claudia Melis; Serenella Deplano; Stefano Alcaro; Francesco Ortuso; Claudiu T Supuran; Elias Maccioni
Journal:  ACS Med Chem Lett       Date:  2020-02-13       Impact factor: 4.345

2.  Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms.

Authors:  Francesca Mancuso; Anna Di Fiore; Laura De Luca; Andrea Angeli; Simona M Monti; Giuseppina De Simone; Claudiu T Supuran; Rosaria Gitto
Journal:  ACS Med Chem Lett       Date:  2020-03-04       Impact factor: 4.345

3.  An Insight into the Structural Requirements and Pharmacophore Identification of Carbonic Anhydrase Inhibitors to Combat Oxidative Stress at High Altitudes: An In-Silico Approach.

Authors:  Amena Ali; Abuzer Ali; Musarrat Husain Warsi; Mohammad Akhlaquer Rahman; Mohamed Jawed Ahsan; Faizul Azam
Journal:  Curr Issues Mol Biol       Date:  2022-02-23       Impact factor: 2.976

4.  Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism.

Authors:  Gul N Shah; Timothy S Rubbelke; Joshua Hendin; Hien Nguyen; Abdul Waheed; James D Shoemaker; William S Sly
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-15       Impact factor: 11.205

5.  Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII.

Authors:  Ylenia Cau; Daniela Vullo; Mattia Mori; Elena Dreassi; Claudiu T Supuran; Maurizio Botta
Journal:  Molecules       Date:  2017-12-22       Impact factor: 4.411

6.  A class of carbonic anhydrase I - selective activators.

Authors:  Erol Licsandru; Muhammet Tanc; Istvan Kocsis; Mihail Barboiu; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2016-11-01       Impact factor: 5.051

7.  Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides.

Authors:  Morteza Abdoli; Andrea Angeli; Murat Bozdag; Fabrizio Carta; Ali Kakanejadifard; Hamid Saeidian; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2017-12       Impact factor: 5.051

Review 8.  Carbonic Anhydrases as Potential Targets Against Neurovascular Unit Dysfunction in Alzheimer's Disease and Stroke.

Authors:  Nicole Lemon; Elisa Canepa; Marc A Ilies; Silvia Fossati
Journal:  Front Aging Neurosci       Date:  2021-11-16       Impact factor: 5.750

Review 9.  Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities.

Authors:  Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

Review 10.  Insights into Potential Targets for Therapeutic Intervention in Epilepsy.

Authors:  Cecilia Zavala-Tecuapetla; Manola Cuellar-Herrera; Hiram Luna-Munguia
Journal:  Int J Mol Sci       Date:  2020-11-13       Impact factor: 5.923
  10 in total

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