INTRODUCTION: Because paradoxical sleep deprivation (PSD) induces a catabolic hormone profile, we sought to evaluate the morphology of the tibialis anterior (TA) muscle and testosterone and corticosterone levels of paradoxical sleep-deprived rats. METHODS: Three study groups of rats were established: the first group was sleep deprived for 96 h; the second group was also sleep deprived for 96 h, but then returned to their home-cage and allowed to sleep for the next 96 h; and the third group was the control group, with a normal sleep cycle. RESULTS: PSD reduced the weight and fiber cross-sectional area of the TA muscle. Moreover, PSD enhanced plasma corticosterone and reduced serum testosterone levels. The 96 h of sleep after PSD was sufficient to restore partially the morphology of TA, while hormones returned to basal levels. CONCLUSION: PSD induces hormonal alterations that may mediate muscle atrophy.
INTRODUCTION: Because paradoxical sleep deprivation (PSD) induces a catabolic hormone profile, we sought to evaluate the morphology of the tibialis anterior (TA) muscle and testosterone and corticosterone levels of paradoxical sleep-deprived rats. METHODS: Three study groups of rats were established: the first group was sleep deprived for 96 h; the second group was also sleep deprived for 96 h, but then returned to their home-cage and allowed to sleep for the next 96 h; and the third group was the control group, with a normal sleep cycle. RESULTS: PSD reduced the weight and fiber cross-sectional area of the TA muscle. Moreover, PSD enhanced plasma corticosterone and reduced serum testosterone levels. The 96 h of sleep after PSD was sufficient to restore partially the morphology of TA, while hormones returned to basal levels. CONCLUSION: PSD induces hormonal alterations that may mediate muscle atrophy.
Authors: Andressa Silva; Marco T Mello; Paula R Serrão; Roberta P Luz; Lia R Bittencourt; Stela M Mattiello Journal: Braz J Phys Ther Date: 2015-09-01 Impact factor: 3.377
Authors: Marcos Mônico-Neto; Sara Quaglia de Campos Giampá; Kil Sun Lee; Camila Maria de Melo; Helton de Sá Souza; Murilo Dáttilo; Paulo Alexandre Minali; Pedro Henrique Santos Prado; Sergio Tufik; Marco Túlio de Mello; Hanna Karen Moreira Antunes Journal: Int J Endocrinol Date: 2015-03-04 Impact factor: 3.257
Authors: Sara Quaglia de Campos Giampá; Marcos Mônico-Neto; Marco Tulio de Mello; Helton de Sá Souza; Sergio Tufik; Kil Sun Lee; Marcia Kiyomi Koike; Alexandra Alberta Dos Santos; Ednei Luiz Antonio; Andrey Jorge Serra; Paulo José Ferreira Tucci; Hanna Karen Moreira Antunes Journal: PLoS One Date: 2016-11-23 Impact factor: 3.240
Authors: Ron C Anafi; Renata Pellegrino; Keith R Shockley; Micah Romer; Sergio Tufik; Allan I Pack Journal: BMC Genomics Date: 2013-05-30 Impact factor: 3.969