BACKGROUND: Epidemiologic studies report that self-identified African Americans typically have higher hemostatic factor levels than do self-identified Caucasians or Hispanics. OBJECTIVE: To enhance understanding of phenotypic variation in hemostatic factor levels by race/ethnicity, we evaluated the relationship between genetic ancestry and hemostatic factor levels among Multi-Ethnic Study of Atherosclerosis (MESA) study participants. PATIENTS/ METHODS: Our sample included 712 African American and 701 Hispanic men and women aged 45 to 84 years. Individual global ancestry was estimated from 199 genetic markers using STRUCTURE. Linear regression models were used to evaluate the relationship between ancestry and hemostatic factor levels, adjusting for age, gender, education, income and study site. RESULTS: Among African Americans, mean ± standard deviation (SD) ancestry was estimated as 79.9% ± 15.9% African and 20.1% ± 15.9% European. Each SD (16%) greater African ancestry was associated with 2.1% higher fibrinogen levels (P = 0.007) and 3.5% higher plasmin-antiplasmin (PAP) levels (P = 0.02). Ancestry among African Americans was not related to levels of factor (F)VIII or D-dimer. Mean ± SD estimated ancestry among Hispanics was 48.3% ± 23.8% Native American, 38.8% ± 21.9% European, and 13.0% ± 8.9% African. In Hispanics, each SD (19%) greater African ancestry was associated with 2.7% higher fibrinogen levels (P = 0.009) and 7.9% higher FVIII levels (P = 0.0002). In Hispanics, there was no relation between African ancestry and D-dimer or PAP levels, or between European ancestry and hemostatic factor levels. CONCLUSIONS: Greater African ancestry among African Americans and Hispanics was associated with higher levels of several hemostatic factors, notably fibrinogen. These results suggest that genetic heterogeneity contributes, albeit modestly, to racial/ethnic differences in hemostatic factor levels.
BACKGROUND: Epidemiologic studies report that self-identified African Americans typically have higher hemostatic factor levels than do self-identified Caucasians or Hispanics. OBJECTIVE: To enhance understanding of phenotypic variation in hemostatic factor levels by race/ethnicity, we evaluated the relationship between genetic ancestry and hemostatic factor levels among Multi-Ethnic Study of Atherosclerosis (MESA) study participants. PATIENTS/ METHODS: Our sample included 712 African American and 701 Hispanic men and women aged 45 to 84 years. Individual global ancestry was estimated from 199 genetic markers using STRUCTURE. Linear regression models were used to evaluate the relationship between ancestry and hemostatic factor levels, adjusting for age, gender, education, income and study site. RESULTS: Among African Americans, mean ± standard deviation (SD) ancestry was estimated as 79.9% ± 15.9% African and 20.1% ± 15.9% European. Each SD (16%) greater African ancestry was associated with 2.1% higher fibrinogen levels (P = 0.007) and 3.5% higher plasmin-antiplasmin (PAP) levels (P = 0.02). Ancestry among African Americans was not related to levels of factor (F)VIII or D-dimer. Mean ± SD estimated ancestry among Hispanics was 48.3% ± 23.8% Native American, 38.8% ± 21.9% European, and 13.0% ± 8.9% African. In Hispanics, each SD (19%) greater African ancestry was associated with 2.7% higher fibrinogen levels (P = 0.009) and 7.9% higher FVIII levels (P = 0.0002). In Hispanics, there was no relation between African ancestry and D-dimer or PAP levels, or between European ancestry and hemostatic factor levels. CONCLUSIONS: Greater African ancestry among African Americans and Hispanics was associated with higher levels of several hemostatic factors, notably fibrinogen. These results suggest that genetic heterogeneity contributes, albeit modestly, to racial/ethnic differences in hemostatic factor levels.
Authors: Noah A Rosenberg; Jonathan K Pritchard; James L Weber; Howard M Cann; Kenneth K Kidd; Lev A Zhivotovsky; Marcus W Feldman Journal: Science Date: 2002-12-20 Impact factor: 47.728
Authors: T W Meade; Y Stirling; S G Thompson; M V Vickers; L Woolf; A B Ajdukiewicz; G Stewart; J F Davidson; I D Walker; A S Douglas Journal: Int J Epidemiol Date: 1986-09 Impact factor: 7.196
Authors: D G Cook; F P Cappuccio; R W Atkinson; P D Wicks; A Chitolie; E R Nakandakare; G A Sagnella; S E Humphries Journal: Am J Epidemiol Date: 2001-04-15 Impact factor: 4.897
Authors: Robert A S Ariëns; Marlies de Lange; Harold Snieder; May Boothby; Tim D Spector; Peter J Grant Journal: Lancet Date: 2002-02-23 Impact factor: 79.321
Authors: Mary Cushman; Aaron R Folsom; Lu Wang; Nena Aleksic; Wayne D Rosamond; Russell P Tracy; Susan R Heckbert Journal: Blood Date: 2002-09-26 Impact factor: 22.113
Authors: Diane E Bild; David A Bluemke; Gregory L Burke; Robert Detrano; Ana V Diez Roux; Aaron R Folsom; Philip Greenland; David R Jacob; Richard Kronmal; Kiang Liu; Jennifer Clark Nelson; Daniel O'Leary; Mohammed F Saad; Steven Shea; Moyses Szklo; Russell P Tracy Journal: Am J Epidemiol Date: 2002-11-01 Impact factor: 4.897
Authors: Thomas A OʼBryan; Brian K Agan; Russell P Tracy; Matthew S Freiberg; Jason F Okulicz; Kaku So-Armah; Anuradha Ganesan; David Rimland; Tahaniyat Lalani; Robert G Deiss; Edmund C Tramont Journal: J Acquir Immune Defic Syndr Date: 2018-04-15 Impact factor: 3.731
Authors: Candace K McClure; Samar R El Khoudary; Carrie A Karvonen-Gutierrez; Kelly R Ylitalo; Kristin Tomey; Trang VoPham; Barbara Sternfeld; Jane A Cauley; Siobán Harlow Journal: Exp Gerontol Date: 2013-11-07 Impact factor: 4.032
Authors: Laura M Raffield; Ake T Lu; Mindy D Szeto; Amarise Little; Kelsey E Grinde; Jessica Shaw; Paul L Auer; Mary Cushman; Steve Horvath; Marguerite R Irvin; Ethan M Lange; Leslie A Lange; Deborah A Nickerson; Timothy A Thornton; James G Wilson; Marsha M Wheeler; Neil A Zakai; Alex P Reiner Journal: J Thromb Haemost Date: 2020-02-20 Impact factor: 5.824
Authors: Neil A Zakai; Leslie A McClure; Suzanne E Judd; Brett Kissela; George Howard; Monika Safford; Mary Cushman Journal: Thromb Haemost Date: 2016-12-22 Impact factor: 5.249
Authors: Laura M Raffield; Neil A Zakai; Qing Duan; Cecelia Laurie; Joshua D Smith; Marguerite R Irvin; Margaret F Doyle; Rakhi P Naik; Ci Song; Ani W Manichaikul; Yongmei Liu; Peter Durda; Jerome I Rotter; Nancy S Jenny; Stephen S Rich; James G Wilson; Andrew D Johnson; Adolfo Correa; Yun Li; Deborah A Nickerson; Kenneth Rice; Ethan M Lange; Mary Cushman; Leslie A Lange; Alex P Reiner Journal: Arterioscler Thromb Vasc Biol Date: 2017-09-14 Impact factor: 8.311
Authors: Godfrey S Temba; Nadira Vadaq; Jun Wan; Vesla Kullaya; Dana Huskens; Tal Pecht; Martin Jaeger; Collins K Boahen; Vasiliki Matzaraki; Wieteke Broeders; Leo A B Joosten; Sultana M H Faradz; Gibson Kibiki; Saskia Middeldorp; Duccio Cavalieri; Paolo Lionetti; Philip G de Groot; Joachim L Schultze; Mihai G Netea; Vinod Kumar; Bas de Laat; Blandina T Mmbaga; Andre J van der Ven; Mark Roest; Quirijn de Mast Journal: J Thromb Haemost Date: 2022-02-10 Impact factor: 16.036