Literature DB >> 2233270

Fluoride stimulates [3H]thymidine incorporation and alkaline phosphatase production by human osteoblasts.

M A Khokher1, P Dandona.   

Abstract

The effect of sodium fluoride on alkaline phosphatase (ALP) release and [3H]thymidine uptake by human osteoblasts in culture was investigated. Sodium fluoride stimulated both ALP release and [3H]thymidine uptake at concentrations of sodium fluoride greater than 250 mumol/L. This stimulation was similar in magnitude to that induced by 1,25-dihydroxycholecalciferol. The fluoride-induced increase in ALP was inhibited by verapamil, a calcium channel blocker. We conclude that sodium fluoride stimulates osteoblasts to proliferate and to release ALP. This stimulation by fluoride is dependent on calcium influx. Fluoride-induced stimulation of human osteoblasts may be relevant to its effect in enhancing bone formation in patients with osteoporosis.

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Year:  1990        PMID： 2233270     DOI： 10.1016/0026-0495(90)90081-m

Source DB:  PubMed          Journal:  Metabolism        ISSN： 0026-0495            Impact factor:   8.694


  11 in total

1.  Sodium fluoride does not increase human bone cell proliferation or protein synthesis in vitro.

Authors:  D J Baylink; J R Farley; K H Lau; J Wergedel
Journal:  Calcif Tissue Int       Date:  1992-01       Impact factor: 4.333

2.  Differential effects of bacterial toxins on mitogenic actions of sodium fluoride and those of aluminum fluoride in human TE85 osteosarcoma cells.

Authors:  H Hashimoto; K H Lau
Journal:  Mol Cell Biochem       Date:  2001-12       Impact factor: 3.396

3.  Dexamethasone enhances the osteogenic effects of fluoride in human TE85 osteosarcoma cells in vitro.

Authors:  J Takada; T Chevalley; D J Baylink; K H Lau
Journal:  Calcif Tissue Int       Date:  1996-05       Impact factor: 4.333

4.  Painful periostitis in the setting of chronic voriconazole therapy.

Authors:  Margaret Skaug; Cedric Spak; Umesh Oza
Journal:  Proc (Bayl Univ Med Cent)       Date:  2014-10

5.  Voriconazole-induced periostitis in two post-transplant patients.

Authors:  Matthew D Bucknor; Andrew J Gross; Thomas M Link
Journal:  J Radiol Case Rep       Date:  2013-08-01

6.  Surface properties and ion release from fluoride-containing bioactive glasses promote osteoblast differentiation and mineralization in vitro.

Authors:  E Gentleman; M M Stevens; R G Hill; D S Brauer
Journal:  Acta Biomater       Date:  2012-11-02       Impact factor: 8.947

Review 7.  Effects of treatment with fluoride on bone mineral density and fracture risk--a meta-analysis.

Authors:  P Vestergaard; N R Jorgensen; P Schwarz; L Mosekilde
Journal:  Osteoporos Int       Date:  2007-08-15       Impact factor: 4.507

8.  In vitro study of osteoblastic cells from patients with idiopathic osteoporosis and comparison with cells from non-osteoporotic controls.

Authors:  M M Wong; L G Rao; H Ly; L Hamilton; S Ish-Shalom; W Sturtridge; J Tong; R McBroom; R G Josse; T M Murray
Journal:  Osteoporos Int       Date:  1994-01       Impact factor: 4.507

9.  Fluoride increases net 45Ca uptake by SaOS-2 cells: The effect is phosphate dependent.

Authors:  J R Farley; S L Hall; S Herring; M A Tanner
Journal:  Calcif Tissue Int       Date:  1993-09       Impact factor: 4.333

10.  Fluoride Regulate Osteoblastic Transforming Growth Factor-β1 Signaling by Mediating Recycling of the Type I Receptor ALK5.

Authors:  Chen Yang; Yan Wang; Hui Xu
Journal:  PLoS One       Date:  2017-01-26       Impact factor: 3.240
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