BACKGROUND: While treatments for the behavioral deficits associated with traumatic brain injury (TBI) are currently limited, animal models suggest that zinc supplementation may increase resilience to TBI. OBJECTIVE: This work tests the hypothesis that zinc supplementation after TBI can be used as treatment to improve behavioral outcomes such as anxiety, depression, and learning and memory. METHODS: TBI was induced by controlled cortical impact to the medial frontal cortex. After TBI, rats were fed either a zinc adequate (ZA, 30 ppm) or zinc supplemented (ZS, 180 ppm) diet. Additional rats in each dietary group (ZA or ZS) were given a single intraperitoneal (ip) injection of zinc (30 mg/kg) 1 hour following injury. RESULTS: Brain injury resulted in significant increases in anxiety-like and depression-like behaviors as well as impairments in learning and memory. None of the zinc treatments (dietary or ip zinc) improved TBI-induced anxiety. The 2-bottle saccharin preference test for anhedonia revealed that dietary ZS also did not improve depression-like behaviors. However, dietary ZS combined with an early ip zinc injection significantly reduced anhedonia (P < .001). Dietary supplementation after injury, but not zinc injection, significantly improved (P < .05) cognitive behavior as measured by the time spent finding the hidden platform in the Morris water maze test compared with injured rats fed a ZA diet. CONCLUSIONS: These data suggest that zinc supplementation may be an effective treatment option for improving behavioral deficits such as cognitive impairment and depression following TBI.
BACKGROUND: While treatments for the behavioral deficits associated with traumatic brain injury (TBI) are currently limited, animal models suggest that zinc supplementation may increase resilience to TBI. OBJECTIVE: This work tests the hypothesis that zinc supplementation after TBI can be used as treatment to improve behavioral outcomes such as anxiety, depression, and learning and memory. METHODS: TBI was induced by controlled cortical impact to the medial frontal cortex. After TBI, rats were fed either a zinc adequate (ZA, 30 ppm) or zinc supplemented (ZS, 180 ppm) diet. Additional rats in each dietary group (ZA or ZS) were given a single intraperitoneal (ip) injection of zinc (30 mg/kg) 1 hour following injury. RESULTS:Brain injury resulted in significant increases in anxiety-like and depression-like behaviors as well as impairments in learning and memory. None of the zinc treatments (dietary or ip zinc) improved TBI-induced anxiety. The 2-bottle saccharin preference test for anhedonia revealed that dietary ZS also did not improve depression-like behaviors. However, dietary ZS combined with an early ip zinc injection significantly reduced anhedonia (P < .001). Dietary supplementation after injury, but not zinc injection, significantly improved (P < .05) cognitive behavior as measured by the time spent finding the hidden platform in the Morris water maze test compared with injured rats fed a ZA diet. CONCLUSIONS: These data suggest that zinc supplementation may be an effective treatment option for improving behavioral deficits such as cognitive impairment and depression following TBI.
Authors: Benjamin Wells de Witt; Kathryn M Ehrenberg; Rose L McAloon; Amanda H Panos; Kaitlyn E Shaw; Priya V Raghavan; Elizabeth R Skidmore; Anthony E Kline Journal: Neurorehabil Neural Repair Date: 2010-12-26 Impact factor: 3.919
Authors: Yaseen M Arabi; Hani M Tamim; Gousia S Dhar; Abdulaziz Al-Dawood; Muhammad Al-Sultan; Maram H Sakkijha; Salim H Kahoul; Riette Brits Journal: Am J Clin Nutr Date: 2011-01-26 Impact factor: 7.045
Authors: Marcin Siwek; Dominika Dudek; Ian A Paul; Magdalena Sowa-Kućma; Andrzej Zieba; Piotr Popik; Andrzej Pilc; Gabriel Nowak Journal: J Affect Disord Date: 2009-03-10 Impact factor: 4.839
Authors: Victor Manuel Blanco-Alvarez; Guadalupe Soto-Rodriguez; Juan Antonio Gonzalez-Barrios; Daniel Martinez-Fong; Eduardo Brambila; Maricela Torres-Soto; Ana Karina Aguilar-Peralta; Alejandro Gonzalez-Vazquez; Constantino Tomás-Sanchez; I Daniel Limón; Jose R Eguibar; Araceli Ugarte; Jeanett Hernandez-Castillo; Bertha Alicia Leon-Chavez Journal: Neural Plast Date: 2015-08-18 Impact factor: 3.599