Literature DB >> 22330239

Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles.

Steven Gunawan, Joachim Petit, Christopher Hulme.   

Abstract

A one-pot, two-step synthesis of bis-pyrrolidinone tetrazoles has been established via the Ugi-Azide reaction using methyl levulinate, primary amines, isocyanides and azidotrimethylsilane with subsequent acid treatment to catalyze the lactam formation. The efficiency of the protocol was established followed by a successful transition to library production in four 24-well plates.

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Year:  2012        PMID： 22330239      PMCID： PMC3299871          DOI： 10.1021/co200209a

Source DB:  PubMed          Journal:  ACS Comb Sci        ISSN： 2156-8944            Impact factor:   3.784


  6 in total

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Review 4.  Recent developments in isocyanide based multicomponent reactions in applied chemistry.

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Review 6.  5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods.

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  6 in total
  15 in total

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2.  Exploiting the Divalent Nature of Isonitriles: a novel Pictet-Spengler Amidination process.

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Review 6.  Tetrazoles via Multicomponent Reactions.

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8.  Ugi 4-CR Synthesis of γ- and δ-Lactams providing new access to diverse enzyme interactions, a PDB analysis.

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