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Literature DB >> 22328990

Nanoparticles act as protein carriers during cellular internalization.

Abstract

Two-colour fluorescence microscopy was used to track the cellular internalization of nanoparticles exposed to extracellular serum proteins. Single particle tracking revealed that nanoparticles and serum proteins are internalized and transported through the cell as a single complex. This study demonstrates the importance of nanoparticle-protein interactions in cellular applications.

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Year: 2012 PMID： 22328990 DOI： 10.1039/c2cc16937a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

15 in total

1. Nanoparticle surface charge mediates the cellular receptors used by protein-nanoparticle complexes.

Authors: Candace C Fleischer; Christine K Payne
Journal: J Phys Chem B Date: 2012-07-20 Impact factor: 2.991

2. Cellular Binding of Anionic Nanoparticles is Inhibited by Serum Proteins Independent of Nanoparticle Composition.

Authors: Candace C Fleischer; Umesh Kumar; Christine K Payne
Journal: Biomater Sci Date: 2013-09-01 Impact factor: 6.843

3. The Effects of Biological Fluids on Colloidal Stability and siRNA Delivery of a pH-Responsive Micellar Nanoparticle Delivery System.

Authors: Dominic W Malcolm; Jomy J Varghese; Janet E Sorrells; Catherine E Ovitt; Danielle S W Benoit
Journal: ACS Nano Date: 2017-12-15 Impact factor: 15.881

Nanoparticles act as protein carriers during cellular internalization.

1. Nanoparticle surface charge mediates the cellular receptors used by protein-nanoparticle complexes.

2. Cellular Binding of Anionic Nanoparticles is Inhibited by Serum Proteins Independent of Nanoparticle Composition.

3. The Effects of Biological Fluids on Colloidal Stability and siRNA Delivery of a pH-Responsive Micellar Nanoparticle Delivery System.

4. Protein Corona in Response to Flow: Effect on Protein Concentration and Structure.

5. Nanoparticle-induced oxidation of corona proteins initiates an oxidative stress response in cells.

6. Impact of Serum Proteins on MRI Contrast Agents: Cellular Binding and T₂ relaxation.

7. Impact of Anti-Biofouling Surface Coatings on the Properties of Nanomaterials and Their Biomedical Applications.

8. Nanoparticle-cell interactions: molecular structure of the protein corona and cellular outcomes.

9. Secondary structure of corona proteins determines the cell surface receptors used by nanoparticles.

10. Could nanoparticle corona characterization help for biological consequence prediction?