| Literature DB >> 22326393 |
Guanghui Wang1, Xiaoyu Guo, Haifeng Chen, Ting Lin, Yang Xu, Quancheng Chen, Jie Liu, Jinzhang Zeng, Xiao-Kun Zhang, Xinsheng Yao.
Abstract
Among the seven natural resveratrol analogs separated and identified from Pholidota yunnanensis R(OLFE), we found phoyunbene B (PYB, trans-3,4'-dihydroxy-2',3',5-trimethoxystilbene) was more effective in inhibiting the growth of HepG2 hepatocellular carcinoma cells than resveratrol. The inhibitory effect of PYB in HepG2 cells was due to its induction of G2/M cell cycle arrest and apoptosis. Induction of G2/M phase cell cycle arrest by PYB was associated with its up-regulation of Cyclin B1, while its induction of apoptosis was accompanied with its down-regulation of Bcl-2 and up-regulation of Bax. Our in vitro invasion/migration assays also showed that PYB could inhibit the invasion of hepatocellular carcinoma cells.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22326393 DOI： 10.1016/j.bmcl.2011.12.095
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823