BACKGROUND: One of the suggested health outcomes of PCB exposure is childhood asthma. OBJECTIVES: This study was conducted to find health relevant biomarkers providing the molecular epidemiological evidence for the positive relationship between exposure to PCBs and childhood asthma. METHODS: Blood samples from fifteen asthmatic children as well as an equal number of non-asthmatic children (average 2 year old) were collected, and were analyzed for PCBs and their select marker expression by using qRT-PCR. RESULTS: Among biomarkers examined IL-8 expression was significantly correlated to serum levels of PCB #163+164 (P=0.022), #170 (P=0.046), #177 (P=0.022), #178 (P=0.022) and #180+193 (P=0.046) in a dose-dependent manner, which was found only among asthmatic children. In contrast, COX-2 correlations to individual congener levels were recognized only among control subjects, not among asthmatic subjects. CONCLUSION: Serum concentrations of PCB#163+164, #170, #177, #178 and #180+193 correlate significantly with IL-8 mRNA expressions among asthmatic children.
BACKGROUND: One of the suggested health outcomes of PCB exposure is childhood asthma. OBJECTIVES: This study was conducted to find health relevant biomarkers providing the molecular epidemiological evidence for the positive relationship between exposure to PCBs and childhood asthma. METHODS: Blood samples from fifteen asthmatic children as well as an equal number of non-asthmatic children (average 2 year old) were collected, and were analyzed for PCBs and their select marker expression by using qRT-PCR. RESULTS: Among biomarkers examined IL-8 expression was significantly correlated to serum levels of PCB #163+164 (P=0.022), #170 (P=0.046), #177 (P=0.022), #178 (P=0.022) and #180+193 (P=0.046) in a dose-dependent manner, which was found only among asthmatic children. In contrast, COX-2 correlations to individual congener levels were recognized only among control subjects, not among asthmatic subjects. CONCLUSION: Serum concentrations of PCB#163+164, #170, #177, #178 and #180+193 correlate significantly with IL-8 mRNA expressions among asthmatic children.
Authors: Christoph Franz Adam Vogel; Sarah Y Kado; Reiko Kobayashi; Xiaoxue Liu; Patrick Wong; Kwangsam Na; Thomas Durbin; Robert A Okamoto; Norman Y Kado Journal: Chemosphere Date: 2018-12-26 Impact factor: 7.086
Authors: Mayumi Tsuji; Toshihiro Kawamoto; Chihaya Koriyama; Fumio Matsumura Journal: Int J Environ Res Public Health Date: 2012-12 Impact factor: 3.390