BACKGROUND: Polymorphisms in SLC11A1 gene have been extensively studied for an association with tuberculosis (TB); however, results from replication studies have been inconsistent. OBJECTIVE: To comprehensively evaluate the genetic risk of polymorphisms (D543N, 3'UTR TGTG ins/del, INT4, [GT]n) in the SLC11A1 gene for TB. METHODS: A meta-analysis was carried out to analyse the association between SLC11A1 polymorphisms and TB risk. RESULTS: A total of 82 case-control studies in 35 articles were included in the meta-analysis. The results showed that these four polymorphisms were associated with an increased risk of TB (D543N OR 1.31, 95%CI 1.11-1.55; 3'UTR TGTG ins/del OR 1.45, 95%CI 1.25-1.68; INT4 OR 1.27, 95%CI 1.09-1.49; [GT]n OR 1.35, 95%CI 1.14-1.61). In further stratified analyses by ethnicity and TB forms, significant increased risks were found in subgroups of Asians and in pulmonary TB (PTB) for all four polymorphisms, while an increased risk of extra-pulmonary TB (EPTB) was found for D543N polymorphism. CONCLUSIONS: This meta-analysis suggests that polymorphisms in the SLC11A1 gene contribute to TB (both PTB and EPTB), particularly in Asians.
BACKGROUND: Polymorphisms in SLC11A1 gene have been extensively studied for an association with tuberculosis (TB); however, results from replication studies have been inconsistent. OBJECTIVE: To comprehensively evaluate the genetic risk of polymorphisms (D543N, 3'UTR TGTG ins/del, INT4, [GT]n) in the SLC11A1 gene for TB. METHODS: A meta-analysis was carried out to analyse the association between SLC11A1 polymorphisms and TB risk. RESULTS: A total of 82 case-control studies in 35 articles were included in the meta-analysis. The results showed that these four polymorphisms were associated with an increased risk of TB (D543N OR 1.31, 95%CI 1.11-1.55; 3'UTR TGTG ins/del OR 1.45, 95%CI 1.25-1.68; INT4 OR 1.27, 95%CI 1.09-1.49; [GT]n OR 1.35, 95%CI 1.14-1.61). In further stratified analyses by ethnicity and TB forms, significant increased risks were found in subgroups of Asians and in pulmonary TB (PTB) for all four polymorphisms, while an increased risk of extra-pulmonary TB (EPTB) was found for D543N polymorphism. CONCLUSIONS: This meta-analysis suggests that polymorphisms in the SLC11A1 gene contribute to TB (both PTB and EPTB), particularly in Asians.
Authors: Juan Manuel Coya; Alexandra Maure; Anne Biton; Roland Brosch; Brigitte Gicquel; Alexandre Giraud-Gatineau; Michael Thomson; Elliott M Bernard; Jade Marrec; Maximiliano G Gutierrez; Gérald Larrouy-Maumus; Ludovic Tailleux Journal: Elife Date: 2020-05-04 Impact factor: 8.140
Authors: M A Huaman; C T Fiske; T F Jones; J Warkentin; B E Shepherd; L A Ingram; F Maruri; T R Sterling Journal: Epidemiol Infect Date: 2014-08-22 Impact factor: 2.451
Authors: Noémi Borsay Hall; Robert P Igo; LaShaunda L Malone; Barbara Truitt; Audrey Schnell; Li Tao; Brenda Okware; Mary Nsereko; Keith Chervenak; Christina Lancioni; Thomas R Hawn; Harriet Mayanja-Kizza; Moses L Joloba; W Henry Boom; Catherine M Stein Journal: Genes Immun Date: 2014-12-18 Impact factor: 2.676