Literature DB >> 22326167

The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone.

Shao-Xing Song1, Ming-Li Wu, Xiao-Peng He, Yu-Bo Zhou, Li Sheng, Jia Li, Guo-Rong Chen.   

Abstract

The anomeric mixture of a series of O-galactolipid derivatives is revealed to be more toxic against several cancer cell lines than their either single component with the pure α- or β-configuration. This interesting phenomenon has been confirmed on pairs of synthesized O-galactosyl anomers bearing length-varied alkyl chains at the lipid end. Furthermore, the most potent mixture was determined inoffensive to a normal cell line tested.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID: 22326167     DOI: 10.1016/j.bmcl.2012.01.069

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Cytotoxic activity of triazole-containing alkyl β-D-glucopyranosides on a human T-cell leukemia cell line.

Authors:  Edward Davis Oldham; Larissa M Nunes; Armando Varela-Ramirez; Stephen E Rankin; Barbara L Knutson; Renato J Aguilera; Hans-Joachim Lehmler
Journal:  Chem Cent J       Date:  2015-02-01       Impact factor: 4.215

2.  Membrane property and biofunction of phospholiposome incorporated with anomeric galactolipids.

Authors:  Danyang Liu; Junqi Zhang; Shouhong Xu; Honglai Liu
Journal:  Springerplus       Date:  2016-05-17
  2 in total

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