OBJECTIVES: Rheumatoid arthritis (RA) is associated with excess cardiovascular (CV) disease. Many studies have shown subclinical atherosclerosis in RA is associated with CV risk factors and inflammation. Their relationship with CV events has however received less attention. Furthermore, except for hypertension CV risk factor management has not been examined in a UK RA population. We therefore evaluated the contribution of RA specific and CV risk factors to CV events alongside the management of CV risk factors in RA patients. METHODS: We assessed the prevalence, screening and treatment of CV risk factors in a cross-sectional survey of RA patients consecutively attending specialist clinics. We used binary logistic regression to examine relationships between CV events and RA and CV risk factors. RESULTS: We enrolled 309 patients (81% female; median age 60 years; median disease duration 8 years). 27 (9%) had previous CV events. 56% had hypertension, 42% hyperlipidaemia, 11% diabetes, 52% were ex/current smokers and 26% obese. Lipid status was unknown in one third. 47% of patients on anti-hypertensive agents were undertreated. CV events were associated with hyperlipidaemia (OR 13.5; 95% CI 3.9, 45.9), hypertension (OR 6.4; 95% CI 1.9, 21.9), having ever smoked (OR 2.7; 95% CI 1.1, 6.5), RA duration (OR 1.09; 95% CI 1.06, 1.13) and erosions (OR 2.9; 95% CI 1.1, 8.2). CONCLUSIONS: CV events are prevalent in RA. They are associated with CV risks and RA factors. Despite this burden we found CV risk factors were inadequately managed. A robust system to identify and treat CV risks in RA is required.
OBJECTIVES:Rheumatoid arthritis (RA) is associated with excess cardiovascular (CV) disease. Many studies have shown subclinical atherosclerosis in RA is associated with CV risk factors and inflammation. Their relationship with CV events has however received less attention. Furthermore, except for hypertension CV risk factor management has not been examined in a UK RA population. We therefore evaluated the contribution of RA specific and CV risk factors to CV events alongside the management of CV risk factors in RApatients. METHODS: We assessed the prevalence, screening and treatment of CV risk factors in a cross-sectional survey of RApatients consecutively attending specialist clinics. We used binary logistic regression to examine relationships between CV events and RA and CV risk factors. RESULTS: We enrolled 309 patients (81% female; median age 60 years; median disease duration 8 years). 27 (9%) had previous CV events. 56% had hypertension, 42% hyperlipidaemia, 11% diabetes, 52% were ex/current smokers and 26% obese. Lipid status was unknown in one third. 47% of patients on anti-hypertensive agents were undertreated. CV events were associated with hyperlipidaemia (OR 13.5; 95% CI 3.9, 45.9), hypertension (OR 6.4; 95% CI 1.9, 21.9), having ever smoked (OR 2.7; 95% CI 1.1, 6.5), RA duration (OR 1.09; 95% CI 1.06, 1.13) and erosions (OR 2.9; 95% CI 1.1, 8.2). CONCLUSIONS: CV events are prevalent in RA. They are associated with CV risks and RA factors. Despite this burden we found CV risk factors were inadequately managed. A robust system to identify and treat CV risks in RA is required.
Authors: Claire E H Barber; Deborah A Marshall; Nanette Alvarez; G B John Mancini; Diane Lacaille; Stephanie Keeling; J Antonio Aviña-Zubieta; Dmitry Khodyakov; Cheryl Barnabe; Peter Faris; Alexa Smith; Raheem Noormohamed; Glen Hazlewood; Liam O Martin; John M Esdaile Journal: J Rheumatol Date: 2015-07-15 Impact factor: 4.666
Authors: Lesley-Anne Bissell; Bara Erhayiem; Graham Fent; Elizabeth M A Hensor; Agata Burska; Helena Donica; Sven Plein; Maya H Buch; John P Greenwood; Jacqueline Andrews Journal: Arthritis Res Ther Date: 2018-12-03 Impact factor: 5.156
Authors: L A Bissell; B Erhayiem; E M A Hensor; G Fent; A Burska; A K McDiarmid; P P Swoboda; H Donica; S Plein; M H Buch; J P Greenwood; J Andrews Journal: Int J Cardiovasc Imaging Date: 2020-02-08 Impact factor: 2.357
Authors: Aneela N Mian; Fowzia Ibrahim; Ian C Scott; Sardar Bahadur; Maria Filkova; Louise Pollard; Sophia Steer; Gabrielle H Kingsley; David L Scott; James Galloway Journal: BMC Musculoskelet Disord Date: 2016-01-27 Impact factor: 2.362
Authors: Eirik Ikdahl; Silvia Rollefstad; Grunde Wibetoe; Anne Salberg; Frode Krøll; Kjetil Bergsmark; Tore K Kvien; Inge C Olsen; Dag Magnar Soldal; Gunnstein Bakland; Åse Lexberg; Clara G Gjesdal; Christian Gulseth; Glenn Haugeberg; Anne Grete Semb Journal: RMD Open Date: 2018-10-01