P Rerknimitr1, W Disphanurat, M Achariyakul. 1. Division of Dermatology, Department of Medicine, Faculty of Medicine, Thammasat University, Pathumthani, Thailand. pawineererk@yahoo.co.th
Abstract
BACKGROUND:Idiopathic guttate hypomelanosis (IGH) is an idiopathic disorder affecting a large number of people. Effective treatments are not yet available. Objectives To investigate the efficacy of topical 0.1% tacrolimus ointment compared with placebo in the treatment of IGH. MATERIALS AND METHODS:Twenty-six patients were included in the study. Lesions on one side of the body were selected to have a treatment with 0.1% tacrolimus ointment, whereas those on the other side served as a control with placebo ointment that had the same physical appearance. Colorimeter was used to assess skin colour at baseline and at 1, 2, 3, 4 and 6 months of treatment. RESULTS:Mean luminosity scale after adjusted for baseline from the treated side gradually decreased and reached statistical significance compared with the control group after 6 months of treatment (P = 0.019). Physicians' improvement grading score showed that 11% of the patients demonstrated improvement of their skin lesions on the treated side after 6 months' treatment. CONCLUSION:Topical 0.1% tacrolimus ointment appeared to be an effective and safe treatment for IGH. The improvements were best observed by colorimetry, yet, they were not statistically significant upon clinical assessments.
RCT Entities:
BACKGROUND:Idiopathic guttate hypomelanosis (IGH) is an idiopathic disorder affecting a large number of people. Effective treatments are not yet available. Objectives To investigate the efficacy of topical 0.1% tacrolimus ointment compared with placebo in the treatment of IGH. MATERIALS AND METHODS: Twenty-six patients were included in the study. Lesions on one side of the body were selected to have a treatment with 0.1% tacrolimus ointment, whereas those on the other side served as a control with placebo ointment that had the same physical appearance. Colorimeter was used to assess skin colour at baseline and at 1, 2, 3, 4 and 6 months of treatment. RESULTS: Mean luminosity scale after adjusted for baseline from the treated side gradually decreased and reached statistical significance compared with the control group after 6 months of treatment (P = 0.019). Physicians' improvement grading score showed that 11% of the patients demonstrated improvement of their skin lesions on the treated side after 6 months' treatment. CONCLUSION: Topical 0.1% tacrolimus ointment appeared to be an effective and safe treatment for IGH. The improvements were best observed by colorimetry, yet, they were not statistically significant upon clinical assessments.
Authors: Celia Zazo Seco; Luciana Serrão de Castro; Josephine W van Nierop; Matías Morín; Shalini Jhangiani; Eva J J Verver; Margit Schraders; Nadine Maiwald; Mieke Wesdorp; Hanka Venselaar; Liesbeth Spruijt; Jaap Oostrik; Jeroen Schoots; Jeroen van Reeuwijk; Stefan H Lelieveld; Patrick L M Huygen; María Insenser; Ronald J C Admiraal; Ronald J E Pennings; Lies H Hoefsloot; Alejandro Arias-Vásquez; Joep de Ligt; Helger G Yntema; Joop H Jansen; Donna M Muzny; Gerwin Huls; Michelle M van Rossum; James R Lupski; Miguel Angel Moreno-Pelayo; Henricus P M Kunst; Hannie Kremer Journal: Am J Hum Genet Date: 2015-10-29 Impact factor: 11.025