Umesh Sharma1, Tahir Tak. 1. Department of Hospital Medicine, Mayo Clinic Health System, La Crosse, WI, USA.
Abstract
BACKGROUND: To counter the possibility of smallpox being used as a biological weapon, in 2002 the US government restarted a smallpox vaccination campaign. Myopericarditis is a possible cardiac complication of smallpox vaccination. We report 2 cases of vaccine-associated myopericarditis in military recruits who were treated at our facility. Chest pain, shortness of breath, and electrocardiographic changes of pericarditis, with a recent history of smallpox vaccination, were useful in making the diagnosis of probable post-vaccinial myopericarditis. Nonsteroidal, anti-inflammatory drugs (NSAIDs) were used to manage myopericarditis. Both patients had complete resolution of symptoms and electrocardiographic changes and subsequently returned to active duty. CONCLUSION: Myopericarditis should be suspected when patients with recent history of smallpox vaccination present with chest pain or shortness of breath. Nonsteroidal anti-inflammatory drugs are useful in the management of post-vaccinial myopericarditis.
BACKGROUND: To counter the possibility of smallpox being used as a biological weapon, in 2002 the US government restarted a smallpox vaccination campaign. Myopericarditis is a possible cardiac complication of smallpox vaccination. We report 2 cases of vaccine-associated myopericarditis in military recruits who were treated at our facility. Chest pain, shortness of breath, and electrocardiographic changes of pericarditis, with a recent history of smallpox vaccination, were useful in making the diagnosis of probable post-vaccinial myopericarditis. Nonsteroidal, anti-inflammatory drugs (NSAIDs) were used to manage myopericarditis. Both patients had complete resolution of symptoms and electrocardiographic changes and subsequently returned to active duty. CONCLUSION: Myopericarditis should be suspected when patients with recent history of smallpox vaccination present with chest pain or shortness of breath. Nonsteroidal anti-inflammatory drugs are useful in the management of post-vaccinial myopericarditis.
Authors: Eva-Maria Zitzmann-Roth; Frank von Sonnenburg; Stephan de la Motte; Nathaly Arndtz-Wiedemann; Alfred von Krempelhuber; Nadine Uebler; Jens Vollmar; Garth Virgin; Paul Chaplin Journal: PLoS One Date: 2015-04-16 Impact factor: 3.240
Authors: Edgar Turner Overton; Steven J Lawrence; Eva Wagner; Katrin Nopora; Siegfried Rösch; Philip Young; Darja Schmidt; Christian Kreusel; Sonja De Carli; Thomas P Meyer; Heinz Weidenthaler; Nathaly Samy; Paul Chaplin Journal: PLoS One Date: 2018-04-13 Impact factor: 3.240