OBJECTIVE: To estimate the heritability of myocardial blood flow (MBF) and coronary flow reserve (CFR) measured with positron emission tomography (PET). DESIGN: Cross-sectional twin study. SETTING: General clinical research centre of a university hospital at Atlanta, USA. PATIENTS: A sample of 180 middle-aged (mean±SD 55±2.9 years) male twins, including 107 monozygotic and 73 dizygotic twins. MAIN OUTCOME MEASURES: All twins underwent imaging of MBF with PET (13)NH(3) at rest and after adenosine stress during a single imaging session. Structural equation modelling was used to estimate the heritability of MBF at rest and during adenosine stress, as well as of CFR. RESULTS: The basal MBF (mean±SD) was 0.69±0.20 ml/min/g, and the MBF during adenosine stress was 1.70±0.49 ml/min/g; the CFR was 2.62±0.99. There was substantial heritability for MBF both at rest (0.48, 95% CI 0.29 to 0.64) and during adenosine stress (0.51, 95% CI 0.29 to 0.68), as well as CFR (0.48, 95% CI 0.26 to 0.65). CONCLUSIONS: For the first time, a substantial genetic contribution to the interindividual variation in MBF and CFR measured with PET in middle-aged men has been demonstrated. The data suggest that a fruitful direction for future work would be the identification of genetic variants for early atherosclerotic stages assessed by PET imaging.
OBJECTIVE: To estimate the heritability of myocardial blood flow (MBF) and coronary flow reserve (CFR) measured with positron emission tomography (PET). DESIGN: Cross-sectional twin study. SETTING: General clinical research centre of a university hospital at Atlanta, USA. PATIENTS: A sample of 180 middle-aged (mean±SD 55±2.9 years) male twins, including 107 monozygotic and 73 dizygotic twins. MAIN OUTCOME MEASURES: All twins underwent imaging of MBF with PET (13)NH(3) at rest and after adenosine stress during a single imaging session. Structural equation modelling was used to estimate the heritability of MBF at rest and during adenosine stress, as well as of CFR. RESULTS: The basal MBF (mean±SD) was 0.69±0.20 ml/min/g, and the MBF during adenosine stress was 1.70±0.49 ml/min/g; the CFR was 2.62±0.99. There was substantial heritability for MBF both at rest (0.48, 95% CI 0.29 to 0.64) and during adenosine stress (0.51, 95% CI 0.29 to 0.68), as well as CFR (0.48, 95% CI 0.26 to 0.65). CONCLUSIONS: For the first time, a substantial genetic contribution to the interindividual variation in MBF and CFR measured with PET in middle-aged men has been demonstrated. The data suggest that a fruitful direction for future work would be the identification of genetic variants for early atherosclerotic stages assessed by PET imaging.
Authors: Helen M Broadbent; John F Peden; Stefan Lorkowski; Anuj Goel; Halit Ongen; Fiona Green; Robert Clarke; Rory Collins; Maria Grazia Franzosi; Gianni Tognoni; Udo Seedorf; Stephan Rust; Per Eriksson; Anders Hamsten; Martin Farrall; Hugh Watkins Journal: Hum Mol Genet Date: 2007-11-29 Impact factor: 6.150
Authors: Ronald C Kessler; Patricia Berglund; Olga Demler; Robert Jin; Kathleen R Merikangas; Ellen E Walters Journal: Arch Gen Psychiatry Date: 2005-06
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Authors: Mao Wang; Patrick Sips; Ester Khin; Maxime Rotival; Ximing Sun; Rizwan Ahmed; Anissa Anindya Widjaja; Sebastian Schafer; Permeen Yusoff; Pervinder Kaur Choksi; Nicole Shi Jie Ko; Manvendra K Singh; David Epstein; Yuguang Guan; Josef Houštěk; Tomas Mracek; Hana Nuskova; Brittney Mikell; Jessie Tan; Francesco Pesce; Frantisek Kolar; Leonardo Bottolo; Massimiliano Mancini; Norbert Hubner; Michal Pravenec; Enrico Petretto; Calum MacRae; Stuart A Cook Journal: Nat Commun Date: 2016-07-08 Impact factor: 14.919