Literature DB >> 223232

A live human B-cell activator operating in isolation of other cellular influences.

A G Bird, S Britton.   

Abstract

Using a reversed haemolytic plaque assay, we demonstrate that live but not inactivated Epstein-Barr (EB) virus can induce human blood lymphocytes to polyclonal Ig (IgM and IgG) secretion in vitro. Unlike pokeweed mitogen this B-cell-activating effect takes place in relative absence of T cells. EB virus thus promises to be a tool for study of B cell function isolated from other cellular influences, although its mechanism of activation appears to be different from that of previously known B cell activators.

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Year:  1979        PMID： 223232     DOI： 10.1111/j.1365-3083.1979.tb03278.x

Source DB:  PubMed          Journal:  Scand J Immunol        ISSN： 0300-9475            Impact factor:   3.487


  17 in total

1.  Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.

Authors:  J D Fingeroth; J J Weis; T F Tedder; J L Strominger; P A Biro; D T Fearon
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

2.  Hemopoietic stem cells and target cells in murine-virus-induced leukemias.

Authors:  H J Seidel
Journal:  J Cancer Res Clin Oncol       Date:  1982       Impact factor: 4.553

3.  Thyroid autoantibody synthesis by cultures of thyroid and peripheral blood lymphocytes. I. Lymphocyte markers and response to pokeweed mitogen.

Authors:  S M McLachlan; A M Dickinson; A Malcolm; J R Farndon; E Young; S J Proctor; B R Smith
Journal:  Clin Exp Immunol       Date:  1983-04       Impact factor: 4.330

4.  Physiology and pathology of rheumatoid factors.

Authors:  D A Carson; J L Pasquali; C D Tsoukas; S Fong; S F Slovin; S K Lawrance; L Slaughter; J H Vaughan
Journal:  Springer Semin Immunopathol       Date:  1981

5.  gp140, the C3d receptor of human B lymphocytes, is also the Epstein-Barr virus receptor.

Authors:  R Frade; M Barel; B Ehlin-Henriksson; G Klein
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

6.  Specific and non-specific B cell activation in measles and varicella.

Authors:  P Arneborn; G Biberfeld; M Forsgren; L V von Stedingk
Journal:  Clin Exp Immunol       Date:  1983-01       Impact factor: 4.330

7.  Human anti-tetanus antibody response in vitro: autologous and allogeneic T cells provide help by different routes.

Authors:  M K Brenner; A J Munro
Journal:  Clin Exp Immunol       Date:  1981-10       Impact factor: 4.330

8.  Effect of Staphylococcus aureus Cowan i bacteria on the mitogenic response of human B-cell subsets.

Authors:  H Harada; T Kasahara; K Ogata; K Shioiri-Nakano; T Kawai
Journal:  Immunology       Date:  1982-11       Impact factor: 7.397

9.  Epstein-Barr virus-transformed lymphocytes produce monoclonal autoantibodies that react with antigens in multiple organs.

Authors:  C Garzelli; F E Taub; J E Scharff; B S Prabhakar; F Ginsberg-Fellner; A L Notkins
Journal:  J Virol       Date:  1984-11       Impact factor: 5.103

10.  IgG production in 'autoimmune' chronic active hepatitis. Effect of prednisolone on T and B lymphocyte function.

Authors:  K T Nouri-Aria; J E Hegarty; G J Alexander; A L Eddleston; R Williams
Journal:  Clin Exp Immunol       Date:  1985-08       Impact factor: 4.330
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