OBJECTIVE: It is an open question whether working memory (WM) and response inhibition (RI) constitute one integral phenotype in attention deficit hyperactivity disorder (ADHD). METHOD: The authors investigated 45 adult ADHD patients and 41 controls comparable for age, gender, intelligence, and education during a letter n-back and a stop-signal task, and measured prefrontal oxygenation by means of functional near-infrared spectroscopy. RESULTS: The authors replicated behavioral and cortical activation deficits in patients compared with controls for both tasks and also for performance in both control conditions. In the patient group, 2-back performance was correlated with stop-signal reaction time. This correlation did not seem to be specific for WM and RI as 1-back performance was correlated with go reaction time. No significant correlations of prefrontal oxygenation between WM and RI were found. CONCLUSION: The authors' findings do not support the hypothesis of WM and RI representing one integral phenotype of ADHD mediated by the prefrontal cortex.
OBJECTIVE: It is an open question whether working memory (WM) and response inhibition (RI) constitute one integral phenotype in attention deficit hyperactivity disorder (ADHD). METHOD: The authors investigated 45 adult ADHDpatients and 41 controls comparable for age, gender, intelligence, and education during a letter n-back and a stop-signal task, and measured prefrontal oxygenation by means of functional near-infrared spectroscopy. RESULTS: The authors replicated behavioral and cortical activation deficits in patients compared with controls for both tasks and also for performance in both control conditions. In the patient group, 2-back performance was correlated with stop-signal reaction time. This correlation did not seem to be specific for WM and RI as 1-back performance was correlated with go reaction time. No significant correlations of prefrontal oxygenation between WM and RI were found. CONCLUSION: The authors' findings do not support the hypothesis of WM and RI representing one integral phenotype of ADHD mediated by the prefrontal cortex.
Entities:
Keywords:
ADHD; impulsivity; n-back; near-infrared spectroscopy; stop signal
Authors: Rubi Hammer; Michael Tennekoon; Gillian E Cooke; Jessica Gayda; Mark A Stein; James R Booth Journal: Dev Cogn Neurosci Date: 2015-06-23 Impact factor: 6.464
Authors: Stefanie C Biehl; Christian J Merz; Thomas Dresler; Julia Heupel; Susanne Reichert; Christian P Jacob; Jürgen Deckert; Martin J Herrmann Journal: Int J Neuropsychopharmacol Date: 2016-05-06 Impact factor: 5.176