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Literature DB >> 22322943

Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20.

Michel V Hadjihannas¹, Dominic B Bernkopf, Martina Brückner, Jürgen Behrens.

Abstract

Wnt/β-catenin signalling regulates cell proliferation by modulating the cell cycle and is negatively regulated by conductin/axin2/axil. We show that conductin levels peak at G2/M followed by a rapid decline during return to G1. In line with this, Wnt/β-catenin target genes are low at G2/M and high at G1/S, and β-catenin phosphorylation oscillates during the cell cycle in a conductin-dependent manner. Conductin is degraded by the anaphase-promoting complex/cyclosome cofactor CDC20. Knockdown of CDC20 blocks Wnt signalling through conductin. CDC20-resistant conductin inhibits Wnt signalling and attenuates colony formation of colorectal cancer cells. We propose that CDC20-mediated degradation of conductin regulates Wnt/β-catenin signalling for maximal activity during G1/S.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22322943 PMCID： PMC3321148 DOI： 10.1038/embor.2012.12

Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 8.807

27 in total

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Journal: EMBO Rep Date: 2010-03-19 Impact factor: 8.807

6. Cell cycle control of wnt receptor activation.

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39 in total

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Review 5. Targeting Cdc20 as a novel cancer therapeutic strategy.

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Journal: Pharmacol Ther Date: 2015-04-04 Impact factor: 12.310

6. Cotargeting Polo-Like Kinase 1 and the Wnt/β-Catenin Signaling Pathway in Castration-Resistant Prostate Cancer.

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Review 7. The way Wnt works: components and mechanism.

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Journal: Growth Factors Date: 2012-12-21 Impact factor: 2.511

8. Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation.

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9. Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans.

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10. Dynamics and evolution of β-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening.

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