OBJECTIVE: We investigated the safety and efficacy of administering influenza vaccines to patients with systemic-onset juvenile idiopathic arthritis (sJIA) treated with tocilizumab. PATIENTS AND METHODS: The subjects were 27 sJIA patients treated with tocilizumab and 17 healthy age- and sex-matched volunteers. Serum samples were collected prior to and 4-7 weeks after vaccination. Hemagglutination inhibition values of the vaccine were taken as the antibody titers. The duration of tocilizumab administration and the daily doses of prednisolone per unit body weight were analyzed to identify factors affecting the responses of the sJIA patients to influenza vaccination. We questioned all the subjects about whether they had contracted influenza and whether they had had adverse reactions to the influenza vaccination. We compared steroid doses in sJIA patients before and after vaccination to document any worsening of the underlying disease. RESULTS: The efficacy of influenza vaccination did not differ significantly between the sJIA group and the healthy controls. The duration of tocilizumab administration did not affect the response of the sJIA patients to the influenza vaccination. None of the sJIA patients experienced either severe adverse reactions or disease exacerbation after the influenza vaccination. CONCLUSION: We found that sJIA patients treated with tocilizumab could be effectively and safely immunized with the influenza vaccine.
OBJECTIVE: We investigated the safety and efficacy of administering influenza vaccines to patients with systemic-onset juvenile idiopathic arthritis (sJIA) treated with tocilizumab. PATIENTS AND METHODS: The subjects were 27 sJIA patients treated with tocilizumab and 17 healthy age- and sex-matched volunteers. Serum samples were collected prior to and 4-7 weeks after vaccination. Hemagglutination inhibition values of the vaccine were taken as the antibody titers. The duration of tocilizumab administration and the daily doses of prednisolone per unit body weight were analyzed to identify factors affecting the responses of the sJIA patients to influenza vaccination. We questioned all the subjects about whether they had contracted influenza and whether they had had adverse reactions to the influenza vaccination. We compared steroid doses in sJIA patients before and after vaccination to document any worsening of the underlying disease. RESULTS: The efficacy of influenza vaccination did not differ significantly between the sJIA group and the healthy controls. The duration of tocilizumab administration did not affect the response of the sJIA patients to the influenza vaccination. None of the sJIA patients experienced either severe adverse reactions or disease exacerbation after the influenza vaccination. CONCLUSION: We found that sJIA patients treated with tocilizumab could be effectively and safely immunized with the influenza vaccine.
Authors: Marc H Jansen; Christien Rondaan; Geertje Legger; Kirsten Minden; Yosef Uziel; Nataša Toplak; Despoina Maritsi; Mirjam van den Berg; Guy Berbers; Patricia Bruijning; Yona Egert; Christophe Normand; Marc Bijl; Helen Foster; Isabelle Kone-Paut; Carine Wouters; Angelo Ravelli; Ori Elkayam; Nicolaas M Wulffraat; Marloes W Heijstek Journal: Front Pediatr Date: 2022-07-06 Impact factor: 3.569
Authors: Luciana M Carvalho; Flávia E de Paula; Rodrigo V D Silvestre; Luciana R Roberti; Eurico Arruda; Wyller A Mello; Virginia P L Ferriani Journal: Pediatr Rheumatol Online J Date: 2013-03-07 Impact factor: 3.054