Literature DB >> 22320959

Needs for hepatocellular carcinoma control policy in the Asia-Pacific region.

John F P Bridges1, Susan M Joy, Gisselle Gallego, Masatoshi Kudo, Sheng-Long Ye, Kwang-Hyub Han, Ann-Lii Cheng, Barri M Blauvelt.   

Abstract

BACKGROUND: Hepatocellular carcinoma (HCC) is particularly burdensome in the Asia-Pacific region, however, cross-country comparisons have been limited to somewhat unreliable epidemiological measures. We conducted a comparative needs assessment for HCC control policy to inform HCC control efforts in the Asia-Pacific region. The aims were to identify regional needs, to compare overall competence across the region, and to identify which needs were concordant across the region.
METHOD: Using the self-explicated method, a stated-preference approach, clinical experts from Australia, China, Japan, Korea, Taiwan, and the United States valued ten previously identified dimensions of HCC control: clinical education; risk assessment; HBV strategy; HCV strategy; life-style risk factors; national statistics; funding for screening; funding for treatment; political awareness; and public awareness. Results were normalized and analyzed using Z-scores and ANOVA, with concordance of need across the region tested via the F-test.
RESULTS: Seventy-two respondents, equally drawn from the study sites, completed the survey (response rate: 36%). Respondents were hepatologists (39%), oncologists (21%), radiologists (17%), surgeons (17%), and other specialists (7%) who were involved in liver cancer control at local/regional (35%) national (44%) or international (21%) levels. In aggregate, the most significant needs were political awareness, public awareness, and life-style risk factors (all p<0.001). Significant differences in aggregate competence were observed across the region (p<0.001), with better than expected competence reported by respondents from Taiwan (p<0.001), Japan (p=0.006), and Korea (0.041), and close to expected competence reported by respondents from Australia, China, and USA (all p>0.05). There were differences in the extent of needs across the region (p<0.05) on all dimensions except funding for screening, clinical education and life style risk factors.
CONCLUSIONS: As the first comparative needs assessment for HCC for the Asia-Pacific region, our results can inform national and cross-national priorities for intervention and facilitate the identification of best practices. Regional efforts to control HCC should adopt as objectives the needs for greater political and public awareness and improved management of lifestyle risk factors because these are the most significant needs, and are shared concerns across the region.

Entities:  

Mesh:

Year:  2011        PMID: 22320959

Source DB:  PubMed          Journal:  Asian Pac J Cancer Prev        ISSN: 1513-7368


  11 in total

1.  CCL18/PITPNM3 enhances migration, invasion, and EMT through the NF-κB signaling pathway in hepatocellular carcinoma.

Authors:  Zeyu Lin; Wenbin Li; Heyun Zhang; Wei Wu; Yaorong Peng; Yunjie Zeng; Yunle Wan; Jie Wang; Nengtai Ouyang
Journal:  Tumour Biol       Date:  2015-10-08

2.  A meta-analysis of the relationship between glutathione S-transferases gene polymorphism and hepatocellular carcinoma in Asian population.

Authors:  Jie Chen; Liang Ma; Ning-Fu Peng; Shi-Jun Wang; Le-Qun Li
Journal:  Mol Biol Rep       Date:  2012-10-10       Impact factor: 2.316

3.  Associations between methylenetetrahydrofolate reductase polymorphisms and hepatocellular carcinoma risk in Chinese population.

Authors:  Xiaosheng Qi; Xing Sun; Junming Xu; Zhaowen Wang; Jinyan Zhang; Zhihai Peng
Journal:  Tumour Biol       Date:  2014-01-03

4.  Wogonoside induces apoptosis in Bel-7402, a hepatocellular carcinoma cell line, by regulating Bax/Bcl-2.

Authors:  Yusheng Li; Min Tu; Chao Cheng; Jian Tian; Fangjie Zhang; Zhenhan Deng; Xuan'an Li; Zhongkui Li; Yanping Liu; Guanghua Lei
Journal:  Oncol Lett       Date:  2015-06-22       Impact factor: 2.967

5.  Variations in the use of diagnostic criteria for developmental dysplasia of the hip.

Authors:  Andreas Roposch; Liang Q Liu; Evangelia Protopapa
Journal:  Clin Orthop Relat Res       Date:  2013-03-21       Impact factor: 4.176

Review 6.  Prevention of hepatocellular carcinoma in chronic viral hepatitis B and C infection.

Authors:  Tao Lu; Wai-Kay Seto; Ran-Xu Zhu; Ching-Lung Lai; Man-Fung Yuen
Journal:  World J Gastroenterol       Date:  2013-12-21       Impact factor: 5.742

7.  Comparison between Platinum-Azidothymidine and Azidothymidine Effects on Bcl-2 and Telomerase Gene Expression in Rats with Hepatocellular Carcinoma.

Authors:  Abdolreza Sabokrouh; Asad Vaisi-Raygani; Mohammad Taghi Goodarzi; Shohreh Khatami; Massoud Taghizadeh-Jahed; Nahid Shahabadi; Niknam Lakpour; Yadollah Shakiba
Journal:  Avicenna J Med Biotechnol       Date:  2015 Apr-Jun

Review 8.  Cancer control programs in East Asia: evidence from the international literature.

Authors:  Malcolm A Moore
Journal:  J Prev Med Public Health       Date:  2014-07-31

9.  Prioritizing strategies for comprehensive liver cancer control in Asia: a conjoint analysis.

Authors:  John F P Bridges; Liming Dong; Gisselle Gallego; Barri M Blauvelt; Susan M Joy; Timothy M Pawlik
Journal:  BMC Health Serv Res       Date:  2012-10-30       Impact factor: 2.655

10.  Microarray profiling shows distinct differences between primary tumors and commonly used preclinical models in hepatocellular carcinoma.

Authors:  Weining Wang; N Gopalakrishna Iyer; Hsien Ts'ung Tay; Yonghui Wu; Tony K H Lim; Lin Zheng; In Chin Song; Chee Keong Kwoh; Hung Huynh; Patrick O B Tan; Pierce K H Chow
Journal:  BMC Cancer       Date:  2015-10-31       Impact factor: 4.430

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