Literature DB >> 2231836

Clinical course and pharmacokinetics following a massive overdose of amphotericin B in a neonate.

G Koren1, A Lau, C F Kenyon, D Kroppert, J Klein.   

Abstract

Amphotericin is the drug of choice for the treatment of fungal infections in infants and children. When used in the recommended doses, amphotericin therapy is associated with high rates of adverse effects, including nephrotoxicity, hepatotoxicity, decrease in white blood cells, platelets and hemoglobin, chills, fever and even death (1). We report a case involving a neonate who was exposed to a 50 fold overdose of Amphotericin over a three day period.

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Year:  1990        PMID: 2231836     DOI: 10.3109/15563659008994438

Source DB:  PubMed          Journal:  J Toxicol Clin Toxicol        ISSN: 0731-3810


  7 in total

Review 1.  Antifungal agents in neonatal systemic candidiasis.

Authors:  J N van den Anker; N M van Popele; P J Sauer
Journal:  Antimicrob Agents Chemother       Date:  1995-07       Impact factor: 5.191

2.  Antifungal agents for the treatment of systemic fungal infections in children.

Authors:  Ud Allen
Journal:  Can J Infect Dis Med Microbiol       Date:  2010       Impact factor: 2.471

3.  Antifungal agents for the treatment of systemic fungal infections in children.

Authors:  Ud Allen
Journal:  Paediatr Child Health       Date:  2010-11       Impact factor: 2.253

4.  A chemically modified tetracycline (CMT-3) is a new antifungal agent.

Authors:  Yu Liu; Maria E Ryan; Hsi-Ming Lee; Sanford Simon; George Tortora; Carol Lauzon; Michael K Leung; Lorne M Golub
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

5.  Amphotericin B in Pediatrics: Analysis by Age Stratification Suggests a Greater Chance of Adverse Events from 13 Months of Age Onwards.

Authors:  Francelise Bridi Cavassin; João Luiz Baú-Carneiro; Fabio de Araújo Motta; Ana Paula Matzenbacher Ville; Leticia Staszczak; Flávio de Queiroz-Telles
Journal:  Paediatr Drugs       Date:  2022-07-18       Impact factor: 3.930

6.  Determinants of aciclovir-induced nephrotoxicity in children.

Authors:  Ruth Schreiber; Jacob Wolpin; Gideon Koren
Journal:  Paediatr Drugs       Date:  2008       Impact factor: 3.022

Review 7.  Antifungal agents and therapy for infants and children with invasive fungal infections: a pharmacological perspective.

Authors:  Jodi M Lestner; P Brian Smith; Michael Cohen-Wolkowiez; Daniel K Benjamin; William W Hope
Journal:  Br J Clin Pharmacol       Date:  2013-06       Impact factor: 4.335

  7 in total

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