Matthew T Naughton1. 1. Department of Allergy, Immunology and Respiratory Medicine, Head, Respiratory and Sleep Medicine Service, Alfred Hospital, Monash University, P.O. Box 315, Prahran, Victoria 3181, Australia. m.naughton@alfred.org.au
Abstract
BACKGROUND: Orthopnoea and paroxysmal nocturnal dyspnoea are common entities regularly confronting thoracic physicians, particularly those with an interest in sleep medicine or non-invasive ventilatory support. One major cause is heart failure (HF), usually associated with abnormal lung function tests, and either obstructive or central sleep apnoea with Cheyne-Stokes respiration (CSA-CSR). Whereas obstructive apnoea is considered injurious to the cardiovascular system, the effects of CSA-CSR are less clear and may be a compensatory response to severe HF. AIM: To determine whether there are compensatory or possibly beneficial aspects caused by CSA-CSR in HF. METHODS: Literature review. RESULTS: CSA-CSR can be detrimental in terms of intermittent hypoxaemia, arousals and autonomic dysregulation. However, it is also associated with the beneficial effects of hyperventilation-related increases in end-expiratory lung volume, intrinsic positive airway pressure, assistance to stroke volume, attenuation of excessive sympathetic nervous activity, avoidance of hypercapnic acidosis and finally the provision of periodic rest to fatigue-prone respiratory pump muscles. CONCLUSIONS: CSA-CSR has physiological features more likely to be compensatory and beneficial than injurious in HF. Some aspects of CSA-CSR are similar to those seen with positive airway pressure.
BACKGROUND:Orthopnoea and paroxysmal nocturnal dyspnoea are common entities regularly confronting thoracic physicians, particularly those with an interest in sleep medicine or non-invasive ventilatory support. One major cause is heart failure (HF), usually associated with abnormal lung function tests, and either obstructive or central sleep apnoea with Cheyne-Stokes respiration (CSA-CSR). Whereas obstructive apnoea is considered injurious to the cardiovascular system, the effects of CSA-CSR are less clear and may be a compensatory response to severe HF. AIM: To determine whether there are compensatory or possibly beneficial aspects caused by CSA-CSR in HF. METHODS: Literature review. RESULTS: CSA-CSR can be detrimental in terms of intermittent hypoxaemia, arousals and autonomic dysregulation. However, it is also associated with the beneficial effects of hyperventilation-related increases in end-expiratory lung volume, intrinsic positive airway pressure, assistance to stroke volume, attenuation of excessive sympathetic nervous activity, avoidance of hypercapnic acidosis and finally the provision of periodic rest to fatigue-prone respiratory pump muscles. CONCLUSIONS: CSA-CSR has physiological features more likely to be compensatory and beneficial than injurious in HF. Some aspects of CSA-CSR are similar to those seen with positive airway pressure.
Authors: Olaf Oldenburg; Birgit Wellmann; Thomas Bitter; Henrik Fox; Anika Buchholz; Eric Freiwald; Dieter Horstkotte; Karl Wegscheider Journal: Clin Res Cardiol Date: 2018-04-13 Impact factor: 5.460